The accumulation of the amyloid-β peptide, the main constituent of the ‘amyloid plaque', is
widely considered to be the key pathological event in Alzheimer's disease. Amyloid-β is …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Dementia with Lewy bodies (DLB) is recognised as the second most common form of
dementia in older people. Delirium is a condition of acute brain dysfunction for which a pre-existing …

Parkinson’s disease (PD) is common and has a number of associated neuropsychiatric
disturbances. Of these, delirium has historically been under-recognised. Delirium is an acute …

Background: Tissue non-specific alkaline phosphatase (TNAP) has been shown to promote
the neurotoxicity of extracellular tau which contributes to the spread of pathology in …

Background: Insulin-like growth factor (IGF)-1 has been implicated in the pathogenesis of
Alzheimer’s disease (AD). Methods: We compared the level of circulating total and …

Impairment of brain-glucose uptake and brain-copper regulation occurs in Alzheimer’s disease
(AD). Here we sought to further elucidate the processes that cause neurodegeneration in …

Background Studies investigating outcomes of delirium using large-scale routine data are
rare. We performed a two-centre study using the 4 ‘A’s Test (4AT) delirium detection tool to …

Alkaline phosphatase is present on neuronal membranes and plasma alkaline phosphatase
activity increases in brain injury and cerebrovascular disease, suggesting that plasma …

Mendelian adult-onset leukodystrophies are a spectrum of rare inherited progressive
neurodegenerative disorders affecting the white matter of the central nervous system. Among these…