Genetic and molecular mechanisms of pulmonary hypertension
N W Morrell and M R Wilkins
DOI: https://doi.org/10.7861/clinmedicine.1-2-138
Clin Med March 2001 N W Morrell
University of Cambridge, Addenbrooke's and Papworth Hospitals
MD MRCPM R Wilkins
Imperial College School of Medicine, Hammersmith Hospital
MD FRCPAbstract
Pulmonary arterial hypertension frequently occurs secondary to common cardiopulmonary diseases, and more rarely as a primary condition. Observations in animals and man have suggested genetic influences underlying the susceptibility to pulmonary hypertension. A gene underlying many cases of familial and apparently sporadic cases of primary pulmonary hypertension has now been identified, and a genetic approach to hypoxia-induced pulmonary hypertension promises to reveal new insights into the unique nature of the pulmonary circulation. The exploration of potential candidate genes influencing susceptibility and the identification of new genes promise new therapeutic approaches to the treatment of pulmonary hypertension.
- © 2001 Royal College of Physicians
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Genetic and molecular mechanisms of pulmonary hypertension
N W Morrell, M R Wilkins
Clinical Medicine Mar 2001, 1 (2) 138-145; DOI: 10.7861/clinmedicine.1-2-138
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