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Acute decompensated heart failure secondary to thiamine deficiency: often a missed diagnosis

Asif Khan and Pankaj Garg
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DOI: https://doi.org/10.7861/clinmedicine.11-2-203a
Clin Med April 2011
Asif Khan
Clinical fellow cardiology
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Pankaj Garg
Cardiology specialist registrar Aintree Cardiac Centre University Hospital Aintree, Liverpool
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Editor – We read with great interest Saunders et al's excellent educational paper (Clin Med December 2010 pp 624–7) on malnutrition. Thiamine deficiency leads to dysfunction of cardiovascular system, commonly known as wet beriberi. This tends to present as acute decompensated heart failure and also with signs of hyperdynamic circulation.1.2 Cardiac beriberi is usually missed in clinical practice because of the absence of classically described symptoms, such as pedal oedema/anasarca. It has been reported that these patients have ongoing myocardial damage with troponin rise.3 Patients in the high risk group of thiamine deficiency are likely to be suffering from chronic alcoholism, social isolation or poor dietary intake, including elderly.4 As the body storage of thiamine is often small, with a high turnover rate and a half life of 10 to 18 days, high risk patients can enter into thiamine deficiency rapidly. Coexisting hypomagnesaemia, a likely result of chronic alcohol abuse, further aggravates the myocardial damaging effect of thiamine deficiency.5

These patients are likely to be diagnosed with idiopathic dilated cardiomyopathy as coronary angiography rules out ischaemic cardiomyopathy. From our experience, erythrocyte transketolase levels are under requested for patients presenting with heart failure.

Treatment of such patients includes usual heart failure management and aggressive replenishment of thiamine. This has been shown to have dramatic response to haemodynamic state in a few hours.1,2

We suggest that thiamine deficiency should be excluded in malnourished patient's presenting with acute decompensated heart failure.

Footnotes

  • Please submit letters for the editor's consideration within three weeks of receipt of Clinical Medicine. Letters should ideally be limited to 350 words, and sent by email to: clinicalmedicine{at}rcplondon.ac.uk

  • Royal College of Physicians

References

  1. ↵
    1. Rao SN
    , Chandak GR. Cardiac beriberi: often a missed diagnosis. J Trop Pediatr 2010;56:284–5.doi:10.1093/tropej/fmp108
    OpenUrlAbstract/FREE Full Text
  2. ↵
    1. Naidoo DP
    , Gathiram V, Sadhabiriss A, Hassen F. Clinical diagnosis of cardiac beriberi. S Afr Med J 1990;77:125–7.
    OpenUrlPubMed
  3. ↵
    1. Tran HA
    . Increased troponin I in ‘wet’ beriberi. J Clin Pathol 2009;59:555.doi:10.1136/jcp.2005.030163
    OpenUrlCrossRef
  4. ↵
    1. Russell RM
    . Vitamin and trace mineral deficiency and excess. In: Braunwald D, Fauci AS, Kasper DL, et al. (eds), Harrison's principles of internal medicine, 15th edn. New York: McGraw-Hill, 2001.
  5. ↵
    1. Martin PR
    , Singleton CK, Hiller-Sturmhofel S. The role of thiamine deficiency in acute brain disease. Alcohol Res Health 2003;27:134–42.
    OpenUrlPubMed

Acute decompensated heart failure secondary to thiamine deficiency: often a missed diagnosis

Wet beriberi is fortunately a rare condition in the western world, even allowing for a degree of underreporting and missed diagnosis. Instead, interest focuses on patients with moderate thiamine deficiency and the potential role in chronic heart failure. The incidence of thiamine deficiency in patients with heart failure is reported to range from 13–98% and is exacerbated by malnutrition and loop-diuretics, which promote thiamine excretion.1–2 There have been mixed results from trials assessing the role of thiamine replacement but one small trial did show some promise with improvements in left ventricular function.3

While it is important to obtain a diagnosis if wet beriberi is clinically suspected, given the relative safety of thiamine replacement, it should not be withheld pending laboratory results. Thiamine testing is relatively expensive, has a long laboratory turn around time and blood analysis in acutely unwell patients may not represent tissue availability.

It is also worth remembering that all characteristic deficiency states are the end result of progressive utilisation of micronutrient stores in an attempt to compensate for the shortfall. Identification of one micronutrient deficiency in an individual from a vulnerable population group should trigger consideration of other subclinical micronutrient deficiencies that may be less apparent.

Footnotes

  • Please submit letters for the editor's consideration within three weeks of receipt of Clinical Medicine. Letters should ideally be limited to 350 words, and sent by email to: clinicalmedicine{at}rcplondon.ac.uk

  • Royal College of Physicians

References

    1. Kwok T
    , Falconer-Smith JF, Potter JF, Ives DR. Thiamine status of elderly patients with cardiac failure. Age Ageing 1992;21:67–71.doi:10.1093/ageing/21.1.67
    OpenUrlAbstract/FREE Full Text
    1. Zenuk C
    , Healey J, Donnelly J et al. Thiamine deficiency in congestive heart failure patients receiving long term furosemide therapy. Can J Clin Pharmacol 2003;10:184–8.
    OpenUrlPubMed
    1. Shimon I
    , Almog S, Vered Z et al. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy. Am J Med 1995;98:485–90.doi:10.1016/S0002-9343(99)80349-0
    OpenUrlCrossRefPubMed
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Acute decompensated heart failure secondary to thiamine deficiency: often a missed diagnosis
Asif Khan, Pankaj Garg
Clinical Medicine Apr 2011, 11 (2) 203-204; DOI: 10.7861/clinmedicine.11-2-203a

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Acute decompensated heart failure secondary to thiamine deficiency: often a missed diagnosis
Asif Khan, Pankaj Garg
Clinical Medicine Apr 2011, 11 (2) 203-204; DOI: 10.7861/clinmedicine.11-2-203a
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