Community-acquired pneumonia
============================

* Jeremy S Brown

## Abstract

Community-acquired pneumonia (CAP) is one of the most common acute infections requiring admission to hospital. The main causative pathogens of CAP are *Streptococcus pneumoniae*, influenza A, *Mycoplasma pneumoniae* and *Chlamydophila pneumoniae*, and the dominant risk factors are age, smoking and comorbidities. The incidence of CAP and its common complications, such as the requirement for intensive care and complicated parapneumonic effusions, are increasing, making it essential for all physicians to have a good understanding of the management of CAP. Although the diagnosis and treatment of CAP is straightforward in most cases, it can be more complex, and recent data indicate that the mortality of CAP in the UK is surprisingly high. In the future, routine use of biomarkers to improve risk stratification and tailor management to individual patients could improve outcomes, and there is some evidence that modulation of CAP-associated inflammation could also be beneficial. Both research into host–microbial interactions in the lung and clinical trials of different management and preventative treatments are urgently needed to combat the increasing morbidity and mortality associated with CAP.

Key Words
*   community-acquired pneumonia
*   infectious disease
*   biomarkers

## Introduction

Community-acquired pneumonia (CAP) is one of the most common serious infective diseases, accounting for nearly 1% of all medical admissions.1 The incidence of CAP in the UK increased by 34% between 1997 and 2005,1 and the rates of serious complications of CAP, such as admissions to intensive care and complicated parapneumonic effusions (CPE), are also on the increase.2,3 This growing burden of disease means that a good understanding of the management of CAP is necessary for any physician caring for acute admissions. Although the diagnosis and management of CAP should be straightforward in most cases, it can be more complex, and recent data indicate that the mortality of CAP in the UK is surprisingly high.4 Here, I provide some background on CAP and address some of the areas of difficulty in managing patients with this disease.

## Causative agents of CAP

The bacterial aetiology of CAP is well established and dictates the choice of empirical antibiotic therapy. The most common causative agent is *Streptococcus pneumoniae*, which is responsible for almost 50% of cases (Table 1);5 other common causes are respiratory viruses (mainly influenza A) and the atypical bacteria *Chlamydophila pneumoniae* and *Mycoplasma pneumoniae*. Less common bacterial causes are *Haemophilus influenzae*, *Staphylococcus aureus*, *Moraxella catarrhalis* and *Legionella pneumophila*. A significant number of patients with CAP have no microbial cause identified, even after extensive testing;5 whether these cases are the result of a novel pathogen or of false negative tests for established pathogens remains unknown. Microorganisms causing CAP reach the lungs either by inhalation of droplets created by sneezing or coughing from an infected contact (eg respiratory viruses, *C. pneumophila* and *M. pneumoniae*) or environmental source (*L. pneumophila*), or by microaspiration after colonisation of the nasopharynx with a potential pathogen (eg *S. pneumoniae, H. influenzae* or *S. aureus*). The reasons for the dominance of *S. pneumoniae* as a cause of CAP compared with other common nasopharyngeal commensals are poorly understood, but if elucidated could help identify novel preventative strategies.

View this table:
[Table 1.](http://www.rcpjournals.org/content/12/6/538/T1)

Table 1. 
Sources of infection and clinical presentation of deep lung infections resulting from important community-acquired microbial pathogens.a

## Immunology and risk factors

Microbial exposure to the lung is constant, but the normal lung has effective immune mechanisms that usually prevent pneumonia. A comprehensive integrated understanding of the normal mechanisms of lung immunity is lacking, but many of the individual components are well known. Initial immune defence depends on effective mucociliary clearance and an intact epithelial barrier, supported by antimicrobial proteins or peptides, such as lactoferrin, lysozyme and defensins. In addition, the airways and alveoli contain alveolar macrophages that recognise and phagocytose invading microorganisms via a range of surface proteins, including scavenger receptors, macrophage receptor with collagenous structure (MARCO), dectin, complement and mannose receptors assisted by opsonins (complement, antibody and surfactants) in the airway-lining fluid. Failure to control invading microorganisms by these initial immune mechanisms triggers an inflammatory response, causing an influx of exudate and white cells into the alveoli and resulting in consolidation, the hallmark of pneumonia. Subsequently, bacteria can potentially invade the blood, where they can be controlled by complement and antibody in combination with phagocytosis by macrophages of the reticuloendothelial system and circulating neutrophils. Additional research is required to identify the relative importance of each of these components for preventing CAP and the potential roles of T cell and other lymphocyte subsets which experimental data suggest are important.

Risk factors for CAP are largely defined by conditions that reduce the efficacy of the normal mechanisms of lung immunity (Table 2). The dominant risk factor is age, with the incidence of CAP increasing markedly in patients who are over 65 years of age (Table 2). As a consequence, CAP affects 2% of people over 85 years of age each year1 and, in a recent British Thoracic Society (BTS) UK-wide audit of CAP, the mean age of patients was 76 years.4 Why increasing age is closely related to the incidence of CAP is not clear, but will be multifactorial. Increasing age is associated with an increasing incidence of coexisting disease that could predispose to CAP; for example, chronic lung disease will reduce the efficiency of mucociliary clearance and neurological comorbidities might increase aspiration, adding to the bacterial load reaching the lungs. Aging increases the expression of the mucosal cell surface proteins that bacteria can adhere to, enabling potential pathogens to better avoid normal clearance mechanisms.6 There is also evidence for direct effects of age on aspects of innate and adaptive immunity, a process called immunosenescence, which will weaken lung immunity to invading microbes.7

View this table:
[Table 2.](http://www.rcpjournals.org/content/12/6/538/T2)

Table 2. 
Defects in lung immunity that result in CAP and their associated risk factors.

## CAP diagnosis and disease severity

Diagnosis of CAP is frequently obvious, with most patients presenting with the combination of evidence for acute infection and new consolidation, usually in an asymmetric lobar distribution. Consolidation is visible on the chest radiograph in over 90% of patients, but occasionally lags behind the clinical presentation and can be difficult to discern in the left lower lobe because of the heart shadow. CAP resulting from *M. pneumoniae* and *C. pneumophila* can present as a predominately small airways infection (a bronchiolitis) rather than as lobar consolidation, causing interstitial changes that are easily missed on poor-quality chest radiographs but readily identified on a CT scan as ‘tree-in-bud’ changes.

Patients with CAP should be assessed for disease severity using the CURB-65 score (or its derivative CRB65).8 The CURB-65 score dictates optimum empirical antibiotic therapy, and whether the patient can be treated safely at home (scores of 0 or 1) or should be admitted to a general (a score of 2) or possibly an intensive care ward (a score of 3+). Although it has been extensively validated and is simple to use, the CURB-65 score has limitations. It is poor at detecting the need for intensive care, with only 51% of patients requiring admission to intensive care units having CURB-65-defined severe disease (a score of 3+).4 In addition, 20% of deaths occur in patients with CURB-65 scores of 2 or lower, and there was a mortality of 8% in the BTS audit for patients with a score of 2.4 Consequently, additional prognostic rules (eg the Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS) minor criteria and SMART-COP) have been designed, but as yet do not have the simplicity and proven validity of the CURB-65 score. Additional clinical indicators of severe disease, such as bilateral or multilobar consolidation, positive blood cultures, acidosis, hypoalbuminaemia and hypoxia, should be used to support risk stratification by CURB-65.8 Numerous biomarkers have also been tested for their utility in improving risk stratification of patients with CAP, including C-reactive protein (CRP), pro-calcitonin (PCT), cytokines and several stress hormones.9 Of these, CRP is the most readily available and does provide additional prognostic data. A CRP of <100 mg/l is independently associated with a lower mortality and >100 mg/l with increased risk of complication by CPE (Table 3).10,11

View this table:
[Table 3.](http://www.rcpjournals.org/content/12/6/538/T3)

Table 3. 
Potential value of CRP as a marker of degree of inflammation for patients presenting with CAP.

## Treatment

Patients admitted to hospital are treated with a combination of a ß lactam and a macrolide, whereas patients treated as outpatients are given single-agent therapy.8 The rationale for dual therapy in patients who are admitted is to cover CAP caused by atypical organisms (ie *M. pneumoniae*, *C. pneumophila* and *L. pneumophila)* as well as by *S. pneumoniae*. Some (but not all) retrospective data show that dual therapy is associated with significantly lower mortality compared with single-agent ß lactam (eg 2.9% versus 11.4% for patients with a CURB-65 score of 2, and 11.1% versus 19.8 for a score of 3+).12 The size of the effect is unlikely to be purely related to treatment of atypical organisms, which in total cause only 20–25% of CAP cases. Macrolides have significant anti-inflammatory effects, which has been exploited for their long-term use in bronchiectasis and cystic fibrosis, and might be beneficial in CAP. Inflammation is required to control microbial numbers, but it causes consolidation and, therefore, the hypoxia associated with CAP. It also contributes to the development of acute respiratory distress syndrome (ARDS) and septic shock, both of which have a high mortality. Hence, it is possible that dual therapy with a macrolide in addition to a b lactam might improve mortality through modulation of the inflammatory response; if so, switching to a single-agent b lactam in patients with proven *S. pneumoniae* CAP might not be beneficial. The potential detrimental effects of excess inflammation might be why statin therapy is associated with improved outcomes in CAP13 and has stimulated trials of systemic corticosteroids in patients with CAP. A recent randomised controlled trial supported the potential therapeutic benefit of systemic corticosteroids for patients with CAP; those given dexamethasone (5 mg intravenously on four occasions) had a more rapid fall in CRP, thus demonstrating a significant effect on the inflammatory response, and a shorter hospital stay (6.5 versus 7.5 days) compared with controls, with no difference in other outcomes.14 However, more research is required on the risks, potential benefits and optimum agents before anti-inflammatory therapy becomes routine for patients with CAP.

There are several problem areas with antibiotic treatment for CAP, including the best choice of antibiotic for patients who are allergic to penicillin. For mild or moderate disease, single-agent macrolide is acceptable but is probably not adequate for severe disease because of the risk of undertreating *S. pneumoniae* and *S. aureus* infection. For patients with a non-anaphylactic penicillin allergy, a second- or third-generation cephalosporin could be used. However, for patients with severe penicillin allergy, all related antibiotics should be avoided, including cephalosporins and penems, and limiting the alternatives to vancomycin, teicoplanin, linezolid or moxifloxacin. Another problem is overtreatment. Only 5% of *S. pneumoniae* isolates in the UK are penicillin resistant and, because this is the result of changes to penicillin-binding proteins, most cases are only partially resistant.15 Therefore, amoxicillin is adequate therapy for most patients with CAP that is not caused by atypical microorganisms. Only the small proportion of patients with CAP resulting from *S. aureus* or Gram-negative bacteria require extended spectrum ß lactams, such as co-amoxiclav or cefuroxime, and these agents should be reserved for patients with a CURB-65 score of 3+. Strict adherence to these guidelines reduced the use of cephalosporins for patients with CAP by 70% without affecting outcomes,16 which should help reduce *Clostridium difficile* infections as well as treatment costs.

Another area of potential overtreatment is the duration of antibiotic therapy, which is traditionally 7 days for patients admitted to hospital, but increasing to 14 days for patients with severe CAP or infected with *S. aureus*, atypical organisms or Gram-negative bacteria. A shorter duration of antibiotic treatment might be adequate for many patients with CAP, but inadequate for others, contributing to an increased risk of complications. An important randomised controlled trial used the levels of the serum marker of inflammation PCT to identify when patients can stop antibiotics.17 The physicians aimed to stop antibiotics when the PCT level fell to <0.25 μg/l; this reduced the median duration of antibiotic use from 12 to five days, with no differences in adverse outcomes between the two groups. These data suggest a more intelligent approach to duration of antibiotic therapy but should be replicated, preferably using a more readily available inflammatory marker, such as CRP.

There is a range of possibilities to be considered if a patient with CAP fails to improve (Table 4). The most common infective complication directly related to CAP is CPE, occurring in approximately 7% of patients admitted to hospital. Local pleural inflammation associated with the underlying consolidation is thought to cause the small parapneumonic effusions that are common in patients with CAP. Parapneumonic effusions become a CPE if there is evidence of infection of the pleural space, either because the pleural fluid contains detectable bacteria, has a low pH (<7.2), or is visibly turbid because of neutrophilia, or because imaging demonstrates that loculations have formed between the visceral and parietal pleura. Loculations are best detected by pleural ultrasound, and ultrasound should also be used to optimise placement of the pleural drains that most patients with CPE require to ensure control of infection and minimise long-term loss of lung function resulting from pleural thickening. Compared with uncomplicated CAP, patients with a CPE have a longer hospital admission (mean of 15 versus 7 days) and duration of antibiotic treatment (3–4 weeks), as well as a high rate of surgical intervention (20–30%) and a significant mortality (30% if over 65 years of age).10,11 Importantly, the incidence of CPE is increasing worldwide,3 stressing the need for a better understanding of the pathogenesis of pleural infection and more effective management strategies.

View this table:
[Table 4.](http://www.rcpjournals.org/content/12/6/538/T4)

Table 4. 
Reasons for failure to improve for patients found to have CAP.

## Mortality

In a recent UK-wide BTS audit, the 30-day mortality of patients with CAP was 18%,4 substantially higher than the 5% and 10% identified by previous studies. This high mortality might reflect the high proportion of older patients in the UK audit, with two thirds above 65 years of age compared with only half for similar data on patients with CAP from Germany.18 However patients over 65 years of age in the German study had a mortality rate of 10%, nearly half that for all ages in the UK audit. The worryingly high mortality for patients with CAP in the UK needs further investigation and the potential reasons why explored in detail. CAP is also associated with a significant late mortality, perhaps related to cardiovascular events, with an additional 6% of patients aged over 65 years dying between 30 and 180 days after diagnosis.18

## Prevention

The relatively high mortality of CAP demonstrates that prevention is important. Behavioural factors that predispose to CAP include smoking (estimated to be responsible for over 30% of cases of CAP)19 and alcohol abuse, both of which can be modified to reduce the incidence of CAP. Owing to the close association of pneumonia with preceding respiratory virus infection, vaccination against influenza is also highly effective at preventing CAP. By contrast, the existing adult *S. pneumoniae* vaccine (Pneumovax) does not prevent pneumonia and the rationale for its use in older people is to prevent sepsis rather than lung infection.20 The new conjugated vaccine might be more immunogenic than Pneumovax, but is routinely used only for children. As yet there are no data on whether vaccination of adults with the conjugated vaccine prevents CAP; trials are in progress and could alter vaccination policy in the future.

## Conclusions

Despite the ready availability of antibiotics and vaccines for important respiratory pathogens, CAP remains a significant and increasingly common medical problem in the industrialised world, with a substantial rate of complication and mortality. In the future, routine use of biomarkers to improve risk stratification and tailor management to individual patients and possibly modulation of CAP-associated inflammation might result in improved outcomes. As well as clinical trials of different management and preventative treatments, further basic research is required on host–microbial interactions in the lung so that clinicians can fully understand why CAP develops and so enable the design of novel therapeutic strategies.

*   © 2012 Royal College of Physicians

## References

1.  1.  Stuart JM
    
    
    
    
    1.  George R, 
    2.  et al
    
    Trotter CL Stuart JM George R, et al. Increasing hospital admissions for pneumonia, England. Emerg Infect Dis 2008; 14:727–33.doi:10.3201/eid1405.071011
    
    [CrossRef](http://www.rcpjournals.org/lookup/external-ref?access_num=10.3201/eid1405.071011&link_type=DOI) 
    
    [PubMed](http://www.rcpjournals.org/lookup/external-ref?access_num=18439353&link_type=MED&atom=%2Fclinmedicine%2F12%2F6%2F538.atom) 
    
    [Web of Science](http://www.rcpjournals.org/lookup/external-ref?access_num=000255508300005&link_type=ISI) 

2.  1.  Welch CA
    
    
    
    
    1.  Harrison DA, 
    2.  et al
    
    Woodhead M Welch CA Harrison DA, et al. Community-acquired pneumonia on the intensive care unit: secondary analysis of 17,869 cases in the ICNARC Case Mix Programme Database. Crit Care 2006; 10:S1.
    
    

3.  1.  Zhu Y
    
    
    
    
    1.  Nuorti JP, 
    2.  et al
    
    Grijalva CG Zhu Y Nuorti JP, et al. Emergence of parapneumonic empyema in the USA. Thorax 2011; 66:663–8.doi:10.1136/thx.2010.156406
    
    [Abstract/FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToidGhvcmF4am5sIjtzOjU6InJlc2lkIjtzOjg6IjY2LzgvNjYzIjtzOjQ6ImF0b20iO3M6Mjc6Ii9jbGlubWVkaWNpbmUvMTIvNi81MzguYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 

4.  1.  Woodhead M
    
    Lim WS Woodhead M British Thoracic Society. British Thoracic Society adult community acquired pneumonia audit 2009/10. Thorax 2011; 66:548–9.doi:10.1136/thoraxjnl-2011-200081
    
    [Abstract/FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToidGhvcmF4am5sIjtzOjU6InJlc2lkIjtzOjg6IjY2LzYvNTQ4IjtzOjQ6ImF0b20iO3M6Mjc6Ii9jbGlubWVkaWNpbmUvMTIvNi81MzguYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 

5.  1.  Macfarlane JT
    
    
    
    
    1.  Boswell TC, 
    2.  et al
    
    Lim WS Macfarlane JT Boswell TC, et al. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines. Thorax 2001; 56:296–301.doi:10.1136/thorax.56.4.296
    
    [Abstract/FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToidGhvcmF4am5sIjtzOjU6InJlc2lkIjtzOjg6IjU2LzQvMjk2IjtzOjQ6ImF0b20iO3M6Mjc6Ii9jbGlubWVkaWNpbmUvMTIvNi81MzguYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 

6.  1.  Orihuela CJ
    
    Boyd AR Orihuela CJ. Dysregulated inflammation as a risk factor for pneumonia in the elderly. Aging Dis 2011; 2:487–500.
    
    [PubMed](http://www.rcpjournals.org/lookup/external-ref?access_num=22288022&link_type=MED&atom=%2Fclinmedicine%2F12%2F6%2F538.atom) 

7.  1.  Brown JS
    
    
    
    
    1.  Thiel A
    
    Baxendale HE Brown JS. Mechanisms of immune protection to pneumococcal infection in the young and the elderly. In: Thiel A (ed), Immunosenescence. Basel: Springer Basel AG 2012:85–126.doi:10.1007/978-3-0346-0219-8_5
    
    [CrossRef](http://www.rcpjournals.org/lookup/external-ref?access_num=10.1007/978-3-0346-0219-8_5&link_type=DOI) 

8.  1.  Baudouin SV
    
    
    
    
    1.  George RC, 
    2.  et al
    
    Lim WS Baudouin SV George RC, et al. BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax 2009; 64:iii1–55.doi:10.1136/thx.2009.121434
    
    [FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiRlVMTCI7czoxMToiam91cm5hbENvZGUiO3M6OToidGhvcmF4am5sIjtzOjU6InJlc2lkIjtzOjE1OiI2NC9TdXBwbF8zL2lpaTEiO3M6NDoiYXRvbSI7czoyNzoiL2NsaW5tZWRpY2luZS8xMi82LzUzOC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=) 

9.  Brown JS. Biomarkers and community-acquired pneumonia. Thorax 2009; 64:556–8.doi:10.1136/thx.2008.110254
    
    [FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiRlVMTCI7czoxMToiam91cm5hbENvZGUiO3M6OToidGhvcmF4am5sIjtzOjU6InJlc2lkIjtzOjg6IjY0LzcvNTU2IjtzOjQ6ImF0b20iO3M6Mjc6Ii9jbGlubWVkaWNpbmUvMTIvNi81MzguYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 

10. 1.  Singanayagam A
    
    
    
    
    1.  Hill AT
    
    Chalmers JD Singanayagam A Hill AT. C-reactive protein is an independent predictor of severity in community-acquired pneumonia. Am J Med 2008; 121:219–25.doi:10.1016/j.amjmed.2007.10.033
    
    [CrossRef](http://www.rcpjournals.org/lookup/external-ref?access_num=10.1016/j.amjmed.2007.10.033&link_type=DOI) 
    
    [PubMed](http://www.rcpjournals.org/lookup/external-ref?access_num=18328306&link_type=MED&atom=%2Fclinmedicine%2F12%2F6%2F538.atom) 
    
    [Web of Science](http://www.rcpjournals.org/lookup/external-ref?access_num=000253824300012&link_type=ISI) 

11. 1.  Singanayagam A
    
    
    
    
    1.  Murray MP, 
    2.  et al
    
    Chalmers JD Singanayagam A Murray MP, et al. Risk factors for complicated parapneumonic effusion and empyema on presentation to hospital with community-acquired pneumonia. Thorax 2009; 64:592–7.doi:10.1136/thx.2008.105080
    
    [Abstract/FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToidGhvcmF4am5sIjtzOjU6InJlc2lkIjtzOjg6IjY0LzcvNTkyIjtzOjQ6ImF0b20iO3M6Mjc6Ii9jbGlubWVkaWNpbmUvMTIvNi81MzguYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 

12. 1.  Welte T
    
    
    
    
    1.  Martus P, 
    2.  et al
    
    Tessmer A Welte T Martus P, et al. Impact of intravenous b-lactam/macrolide versus b-lactam monotherapy on mortality in hospitalized patients with community-acquired pneumonia. J Antimicrob Chemother 2009; 63:1025–33.
    
    [Abstract/FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamFjIjtzOjU6InJlc2lkIjtzOjk6IjYzLzUvMTAyNSI7czo0OiJhdG9tIjtzOjI3OiIvY2xpbm1lZGljaW5lLzEyLzYvNTM4LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==) 

13. 1.  Singanayagam A
    
    
    
    
    1.  Murray MP, 
    2.  et al
    
    Chalmers JD Singanayagam A Murray MP, et al. Prior statin use is associated with improved outcomes in community-acquired pneumonia. Am J Med 2008; 121:1002–7.doi:10.1016/j.amjmed.2008.06.030
    
    [CrossRef](http://www.rcpjournals.org/lookup/external-ref?access_num=10.1016/j.amjmed.2008.06.030&link_type=DOI) 
    
    [PubMed](http://www.rcpjournals.org/lookup/external-ref?access_num=18954848&link_type=MED&atom=%2Fclinmedicine%2F12%2F6%2F538.atom) 
    
    [Web of Science](http://www.rcpjournals.org/lookup/external-ref?access_num=000260369900015&link_type=ISI) 

14. 1.  Hardeman H
    
    
    
    
    1.  Remmelts HH, 
    2.  et al
    
    Meijvis SC Hardeman H Remmelts HH, et al. Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet 2011; 377:2023–30.doi:10.1016/S0140-6736(11)60607-7
    
    [CrossRef](http://www.rcpjournals.org/lookup/external-ref?access_num=10.1016/S0140-6736(11)60607-7&link_type=DOI) 
    
    [PubMed](http://www.rcpjournals.org/lookup/external-ref?access_num=21636122&link_type=MED&atom=%2Fclinmedicine%2F12%2F6%2F538.atom) 
    
    [Web of Science](http://www.rcpjournals.org/lookup/external-ref?access_num=000292011700037&link_type=ISI) 

15. 1.  Henderson KL
    
    
    
    
    1.  Lillie M, 
    2.  et al
    
    Blackburn RM Henderson KL Lillie M, et al. Empirical treatment of influenza-associated pneumonia in primary care: a descriptive study of the antimicrobial susceptibility of lower respiratory tract bacteria (England, Wales and Northern Ireland, January 2007-March 2010). Thorax 2011; 66:389–95.doi:10.1136/thx.2010.134643
    
    [Abstract/FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToidGhvcmF4am5sIjtzOjU6InJlc2lkIjtzOjg6IjY2LzUvMzg5IjtzOjQ6ImF0b20iO3M6Mjc6Ii9jbGlubWVkaWNpbmUvMTIvNi81MzguYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 

16. 1.  Singanayagam A
    
    
    
    
    1.  Akram AR, 
    2.  et al
    
    Chalmers JD Singanayagam A Akram AR, et al. Safety and efficacy of CURB65-guided antibiotic therapy in community-acquired pneumonia. J Antimicrob Chemother 2011; 66:416–23.doi:10.1093/jac/dkq426
    
    [Abstract/FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamFjIjtzOjU6InJlc2lkIjtzOjg6IjY2LzIvNDE2IjtzOjQ6ImF0b20iO3M6Mjc6Ii9jbGlubWVkaWNpbmUvMTIvNi81MzguYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 

17. 1.  Stolz D
    
    
    
    
    1.  Bingisser R, 
    2.  et al
    
    Christ-Crain M Stolz D Bingisser R, et al. Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med 2006; 174:84–93.doi:10.1164/rccm.200512-1922OC
    
    [CrossRef](http://www.rcpjournals.org/lookup/external-ref?access_num=10.1164/rccm.200512-1922OC&link_type=DOI) 
    
    [PubMed](http://www.rcpjournals.org/lookup/external-ref?access_num=16603606&link_type=MED&atom=%2Fclinmedicine%2F12%2F6%2F538.atom) 
    
    [Web of Science](http://www.rcpjournals.org/lookup/external-ref?access_num=000238502600014&link_type=ISI) 

18. 1.  Ewig S
    
    
    
    
    1.  Pletz MW, 
    2.  et al
    
    Klapdor B Ewig S Pletz MW, et al. Community-acquired pneumonia in younger patients is an entity on its own. Eur Respir J 2012; 39:1156–61.doi:10.1183/09031936.00110911
    
    [Abstract/FREE Full Text](http://www.rcpjournals.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiZXJqIjtzOjU6InJlc2lkIjtzOjk6IjM5LzUvMTE1NiI7czo0OiJhdG9tIjtzOjI3OiIvY2xpbm1lZGljaW5lLzEyLzYvNTM4LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==) 

19. 1.  Gonzalez CA
    
    
    
    
    1.  Balanzo X, 
    2.  et al
    
    Almirall J Gonzalez CA Balanzo X, et al. Proportion of community-acquired pneumonia cases attributable to tobacco smoking. Chest 1999; 116:375–9.doi:10.1378/chest.116.2.375
    
    [CrossRef](http://www.rcpjournals.org/lookup/external-ref?access_num=10.1378/chest.116.2.375&link_type=DOI) 
    
    [PubMed](http://www.rcpjournals.org/lookup/external-ref?access_num=10453865&link_type=MED&atom=%2Fclinmedicine%2F12%2F6%2F538.atom) 
    
    [Web of Science](http://www.rcpjournals.org/lookup/external-ref?access_num=000081950400018&link_type=ISI) 

20. 1.  Holden J
    
    
    
    
    1.  Tatham DP, 
    2.  et al
    
    Moberley SA Holden J Tatham DP, et al. Vaccines for preventing pneumococcal infection in adults. Cochrane Database Syst Rev 2008; 23:CD000422.doi:10.1002/14651858.CD000422.pub2
    
    [CrossRef](http://www.rcpjournals.org/lookup/external-ref?access_num=10.1002/14651858.CD000422.pub2&link_type=DOI)