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Risk of developing acute kidney injury (AKI) following the administration of iodinated contrast medium

Derrick Martin and Alison Bradley
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DOI: https://doi.org/10.7861/clinmedicine.12-6-607a
Clin Med December 2012
Derrick Martin
Radiology Department, Wythenshawe Hospital, Manchester
Roles: Professor of gastrointestinal radiology
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Alison Bradley
Radiology Department, Wythenshawe Hospital, Manchester
Roles: Consultant uroradiologist
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Editor – We were pleased to see the article entitled ‘Acute kidney injury: top ten tips’ by Prescott, Lewington and O'Donoghue and its logical pragmatic advice for protecting patients from in-hospital acute kidney injury (Clin Med August 2012 pp328–32). However, we were disappointed by the missed opportunity to alert physicians to the potential renal injury caused by iodinated contrast medium (CM). While large volumes of CM are used for angiographic imaging and intervention, by far the largest volume of CM is used for enhanced computed tomography (CT). We estimate in our hospital alone, we give over 600 litres of CM to patients undergoing CT annually. Even with modern low osmolar and iso-osmolar CM, there is a risk of generating contrast induced nephropathy (CIN) in patients with already limited renal function. CIN is defined as an increase in serum creatinine of >25 µg/l over baseline, or an absolute rise of >44 µg/l. Patients with GFR <60 ml/min are at risk, which rises sharply when GFR falls below 40 ml/min.1

The demand for CT is steadily rising. Most radiology departments experience CT demand increasing by approximately 10% annually at present. While the high radiation dose of body CT has been a disincentive to its use, CT machine manufacturers are working hard to improve image quality, while limiting or reducing radiation dose. This means that CT will be more widely used for the assessment of acute thoracic and abdominal pathology. Cancer staging and the follow up of chronic conditions such as inflammatory bowel disease will further increase the need for CT. Barium enema is obsolete – its place is taken by CT colonography. These factors will increase demand for CT in an ageing population and physicians referring patients for imaging must be aware of the risk posed to their patients by CM administration. Good guidelines for the pre-procedural management of patients are available.2 We need not reiterate what is already published, but would urge physicians to familiarise themselves with the risk associated with CM administration and pre-emptive measures aimed at mitigating these.

Footnotes

  • Please submit letters for the editor's consideration within three weeks of receipt of Clinical Medicine. Letters should ideally be limited to 350 words, and sent by email to: clinicalmedicine{at}rcplondon.ac.uk

  • © 2012 Royal College of Physicians

References

  1. ↵
    1. Thomsen HS
    , Morcos SK. Risk of contrast-medium induced nephrotoxicity in high risk patients undergoing MDCT – a pooled analysis of two randomised trials. Eur Radiol 2009; 19:891–897.
    OpenUrlCrossRefPubMed
  2. ↵
    European Society of Urogenital Radiology. ESUR guidelines on contrast media. Version 7. Vienna: ESUR, 2008. www.esur.org/ESUR-Guidelines.23.0.html [Accessed 8 October 2012].

Risk of developing acute kidney injury (AKI) following the administration of iodinated contrast medium

Thank you for your letter highlighting the risk of developing acute kidney injury (AKI) following the administration of iodinated contrast medium. We agree that this is an important cause of AKI and one that all physicians should be aware of. The primary purpose of our article was to provide an overview of the processes that need to be implemented to improve the recognition and response to patients at risk of, or who develop, AKI. The recommended processes include the development of local guidelines that should include the prevention of contrast induced AKI (CI-AKI).

The incidence of CI-AKI is estimated at 1–2% in patients with normal kidney function, even in those with diabetes. However, it is the third most common cause of in-hospital AKI after renal hypoperfusion and nephrotoxic medication.1,2 Furthermore, the incidence of CI-AKI increases significantly in patients with risk factors and is associated with increased mortality. It can occur within 72 hours of receiving iodinated contrast media as a result of afferent arteriolar vasoconstriction and direct toxicity of the contrast to the kidney tubular epithelial cells.

The international guideline group, Kidney Disease: Improving Global Outcomes (KDIGO), recommends that CI-AKI is defined as a rise in serum creatinine by >26 µmol/l within 48 hours, or a rise in serum creatinine by >1.5 fold from baseline value (which is known or presumed to have occurred within one week) or a urine output of, 0.5 ml/kg/hr for more than six consecutive hours.3 This will allow harmonisation of the definition of CI-AKI with all forms of AKI.

Prevention of CI-AKI is essential as there is no specific treatment. The Renal Association recommend baseline kidney function be assessed and other risk factors for CI-AKI identified prior to imaging with iodinated contrast media.4 Risk factors for CI-AKI include chronic kidney disease (eGFR, 60 ml/min/1.73m2), older age (.75 years), cardiac failure, nephrotoxic medication, hypovolaemia, sepsis and the use of large volumes of contrast. While the estimated glomerular filtration rate can be used to assess kidney function in stable outpatients, serum creatinine should be used for acutely ill patients and those with AKI.

In patients identified as being at high risk of CI-AKI, alternative forms of imaging, such as ultrasound scan or magnetic resonance angiography, should be considered. Where alternative imaging techniques are not appropriate, the risk of developing CI-AKI should be minimised by appropriate volume expansion with intravenous 0.9% sodium chloride or isotonic sodium bicarbonate at a rate of 1 ml/kg/hr for 12 hours pre- and post-procedure, withholding potentially nephrotoxic medications, and minimising the dose of contrast appropriately. Kidney function should be checked 48–72 hours post-procedure and further exposure to iodinated contrast media delayed until full recovery of kidney function.4

As you state in your letter, the demand for enhanced computed tomography (CT) in everyday clinical practice is increasing and with this the exposure of increasingly complex and acutely ill patients to iodinated contrast media. We would urge all hospitals to develop local guidelines for the prevention of CI-AKI.

Footnotes

  • Please submit letters for the editor's consideration within three weeks of receipt of Clinical Medicine. Letters should ideally be limited to 350 words, and sent by email to: clinicalmedicine{at}rcplondon.ac.uk

  • © 2012 Royal College of Physicians

References

  1. ↵
    1. Stacul F
    , Adam A, Becker CR, et al. Strategies to reduce the risk of contrast-induced nephropathy. Am J Cardiol 2006; 98:59K–77K.doi:10.1016/j.amjcard.2006.01.024
    OpenUrlCrossRefPubMed
  2. ↵
    1. Shaw DR
    , Kessel DO. The current status of the use of carbon dioxide in diagnostic and interventional angiographic procedures. Cardiovasc Intervent Radiol 2006; 29:323–331.doi:10.1007/s00270-005-0092-2
    OpenUrlCrossRefPubMed
  3. Kidney Disease: Improving Global Outcomes. (KDIGO). Clinical Practice Guideline for Acute Kidney Injury. New York: KDIGO, 2012. www.kdigo.org/clinical_practice_guidelines/AKI.php [Accessed 8 October 2012].
    1. Lewington AJP
    , Kanagasundaram NS. Acute Kidney Injury, 5th Clinical Practice Guidelines. Nephron Clin Pract 2011; 118(Suppl 1):c27–70.
    OpenUrlPubMed
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Risk of developing acute kidney injury (AKI) following the administration of iodinated contrast medium
Derrick Martin, Alison Bradley
Clinical Medicine Dec 2012, 12 (6) 607-608; DOI: 10.7861/clinmedicine.12-6-607a

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Risk of developing acute kidney injury (AKI) following the administration of iodinated contrast medium
Derrick Martin, Alison Bradley
Clinical Medicine Dec 2012, 12 (6) 607-608; DOI: 10.7861/clinmedicine.12-6-607a
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