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An unusual cause of vomiting

Ben Warner, Beth Davies, Deepak Joshi, Stuart Cairns and Mark Austin
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DOI: https://doi.org/10.7861/clinmedicine.13-5-522
Clin Med October 2013
Ben Warner
1Department of Gastroenterology, Digestive Diseases Centre, Royal Sussex County Hospital, Brighton, UK
Roles: ST5 gastroenterology
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  • For correspondence: b.warner@uclmail.net
Beth Davies
1Department of Gastroenterology, Digestive Diseases Centre, Royal Sussex County Hospital, Brighton, UK
Roles: CT2
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Deepak Joshi
1Department of Gastroenterology, Digestive Diseases Centre, Royal Sussex County Hospital, Brighton, UK
Roles: ST7 gastroenterology
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Stuart Cairns
1Department of Gastroenterology, Digestive Diseases Centre, Royal Sussex County Hospital, Brighton, UK
Roles: consultant gastroenterology
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Mark Austin
1Department of Gastroenterology, Digestive Diseases Centre, Royal Sussex County Hospital, Brighton, UK
Roles: consultant gastroenterology
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KEY WORDS
  • Liver failure
  • abdominal pain
  • intestinal obstruction
  • liver cirrhosis
  • imaging

Key learning points

‘Cocoon syndrome’ is a possible differential in patients with end-stage cirrhosis who present with vomiting and abdominal symptoms.

Recurrent inflammation of the peritoneum from spontaneous bacterial peritonitis (SBP) leads to encasement of the bowel.

Computed tomography (CT) is the main imaging modality to reach this diagnosis.

Antibiotics, parenteral nutrition and bowel rest are the standard immediate treatments.

Clinical presentation

A 45-year-old female with ascites and known alcohol cirrhosis (model for end-stage liver disease [MELD] score of 26 and Child–Pugh score of 12) presented with fever, abdominal pain and ­vomiting. Relevant past medical history included an episode of spontaneous bacterial peritonitis (SBP) 4 weeks previously with an E coli grown from ascites on enrichment. The patient had been discharged previously and prescribed norfloxacin (400 mg once daily). Clinical examination revealed a distended abdomen but no pyrexia (body temperature 36.5°C). Blood tests demonstrated a leucocytosis (27.4 × 109/l, normal range 3.4–11), deranged liver synthetic function (albumin 22 g/l, bilirubin 200 μmol/l, international normalised ratio [INR] 2.5). A diagnostic ascitic tap ­demonstrated a white cell count of 150 × 106/l. Empirical anti­biotics were commenced following a septic screen. Due to persistent vomiting and recurrent pyrexia a computed tomography (CT) scan of the abdomen was performed (Fig 1 and 2).

Fig 1.
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Fig 1.

CT scan of the abdomen showing dilated thickened small bowel loops consistent with abdominal cocooning. CT = computed tomography.

What does the imaging show and what is the unifying diagnosis?

Fig 1 demonstrates dilated thickened small bowel loops consistent with abdominal cocooning. Fig 2 showed loculated ascites with a cirrhotic liver. A repeat ascitic tap demonstrated ongoing peritoneal sepsis (white cell count 4,800 × 106/l). The unifying diagnosis was small bowel ileus, secondary to ongoing peritoneal sepsis, with evidence of an abdominal cocoon.

Fig 2.
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Fig 2.

CT scan of the abdomen showing loculated ascites with a cirrhotic liver. CT = computed tomography.

Abdominal cocooning or sclerosing encapsulating peritonitis (SEP) can be idiopathic, affecting mainly young females in tropical countries, or can occur as a complication of continuous ambulatory peritoneal dialysis or prior abdominal surgery. It has also been reported in patients with cirrhosis and abdominal tuberculosis (TB).1–4

Inflammation of the peritoneum leads to the formation of a membrane which encases the abdominal viscera, preventing gut motility and causing symptoms of sub-acute bowel obstruction.2 Clinical examination reveals a tender abdomen and even a palpable mass.5 Imaging modality of choice is an abdominal CT scan, which is able to demonstrate encased small bowel loops and peritoneal inflammation. The initial management should include the treatment of peritoneal sepsis, nutritional support and bowel rest. A transjugular intrahepatic portosystemic shunt (TIPSS) procedure can be performed for treatment of the ascites followed by ‘­cocoonectomy’ and wash-out at laparotomy, but this remains high risk.

  • © 2013 Royal College of Physicians

References

  1. ↵
    1. Xu P,
    2. Chen LH,
    3. Li YM
    . Idiopathic sclerosing encapsulating peritonitis (or abdominal cocoon): a report of 5 cases. World J Gastroenterol 2007;13:3649–51.
    OpenUrlPubMed
  2. ↵
    1. Tannoury J,
    2. Abboud B
    . Idiopathic sclerosing encapsulating peritonitis: abdominal cocoon. World J Gastroenterology 2012;18:1999–2004.doi:10.3748/wjg.v18.i17.1999
    OpenUrlCrossRefPubMed
  3. ↵
    1. Noormohamed MS,
    2. Kadi N
    . Abdominal cocoon in peritoneal dialysis – a fatal outcome. BMJ Case Rep 2012; doi:10.1136/bcr.01.2012.5581.
  4. ↵
    1. Gadodia A,
    2. Sharma R,
    3. Jeyaseelan N
    . Tuberculous abdominal cocoon. Am J Trop Med Hyg 2011;84:000–2.
    OpenUrl
  5. ↵
    1. Wei B,
    2. Wei HB,
    3. Guo WP,
    4. et al.
    Diagnosis and treatment of abdominal cocoon: a report of 24 cases. Am J Surg 2009;198:348–53.doi:10.1016/j.amjsurg.2008.07.054
    OpenUrlCrossRefPubMed
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An unusual cause of vomiting
Ben Warner, Beth Davies, Deepak Joshi, Stuart Cairns, Mark Austin
Clinical Medicine Oct 2013, 13 (5) 522-523; DOI: 10.7861/clinmedicine.13-5-522

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An unusual cause of vomiting
Ben Warner, Beth Davies, Deepak Joshi, Stuart Cairns, Mark Austin
Clinical Medicine Oct 2013, 13 (5) 522-523; DOI: 10.7861/clinmedicine.13-5-522
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