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Transcatheter aortic valve implantation – what the general physician needs to know

Neil Ruparelia and Bernard D Prendergast
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DOI: https://doi.org/10.7861/clinmedicine.15-5-420
Clin Med October 2015
Neil Ruparelia
AHammersmith Hospital, Imperial College, London, UK, and Oxford Heart Centre, John Radcliffe Hospital, Oxford, UK
Roles: interventional cardiology fellow
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Bernard D Prendergast
BSt Thomas’ Hospital, London, UK
Roles: consultant cardiologist
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  • For correspondence: bernard.prendergast@gstt.nhs.uk
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ABSTRACT

With an increasingly elderly population, the incidence of aortic stenosis (AS) is rising. While surgical aortic valve replacement remains the gold standard treatment for patients with severe symptomatic AS, transcatheter aortic valve implantation (TAVI) has emerged as the treatment of choice for patients who are inoperable or high surgical risk. TAVI has been shown to be associated with a clear mortality benefit when compared with medical therapy and to be at least as good as surgical aortic valve replacement in this patient group. The last few years have seen rapid development in this revolutionary technology in conjunction with increasing centre and operator experience, and indications for the procedure are swiftly expanding. In this review, we summarise the current evidence base and discuss factors that need to be considered by the general physician when contemplating TAVI as a treatment option, including practical aspects, emerging indications and future directions.

KEYWORDS
  • Aortic stenosis
  • transcatheter aortic valve implantation
  • TAVI
  • aortic valve replacement

Introduction

With an increasingly elderly population, general physicians commonly encounter patients with aortic stenosis (AS), which has a prevalence of 4.6% in those aged greater than 75 years.1 The majority of patients are asymptomatic and the diagnosis of AS is often an incidental finding (usually in the setting of another medical condition). In these individuals, AS is associated with low mortality.2 However, the onset of symptoms in severe AS is associated with a bleak prognosis and 50% mortality within two years without definitive treatment.3

The gold standard treatment for severe AS remains surgical aortic valve replacement (SAVR), which is associated with excellent outcomes in contemporary practice.4 However, a significant minority of patients presenting to the medical team have multiple comorbidities which are often compounded by significant frailty. In these patients, SAVR is associated with a 5–10% risk of major adverse perioperative events and a mortality of up to 20% at one year.5 Given this prohibitively high surgical risk, these patients have historically refused or been denied surgery with no alternative treatment option.

Following the first successful human implantation in 2002,6 transcatheter aortic valve implantation (TAVI) has rapidly developed over the past few years and is now the established treatment option for inoperable or high-risk surgical patients with severe symptomatic AS.7 In this article, we will summarise the current evidence base and discuss factors that need to be taken into account by the general physician when considering TAVI as a treatment option, including practical aspects and future directions.

Current evidence

Following the first successful TAVI in 2002,6 the feasibility, efficacy and safety of the procedure were subsequently confirmed in a number of single- and multi-centre registries.8

The Placement of AoRTic TraNscathetER Valves (PARTNER) trials were the first prospective randomised studies to compare outcomes of TAVI using the balloon-expandable (BE) Edwards Sapien valve (Edwards LifeSciences, Irvine, CA, USA) with medical management in inoperable patients9 (cohort B) and with SAVR in patients of high surgical risk (cohort A).10 When compared with medical therapy (plus balloon aortic valvuloplasty as required), TAVI resulted in a significant reduction in one-year mortality (30.7 vs 50.1%) that was maintained at three-year follow-up (54.1 vs 80.9%).11 When TAVI was compared with SAVR in high-risk individuals, all-cause mortality was slightly lower with TAVI at 30 days (3.4 vs 6.5%, p = 0.07) but comparable three years following implantation (44.2 vs 44%) with long-term symptomatic improvement sustained in both groups.12

Of late, results of two more contemporary TAVI trials were reported. The non-randomised CoreValve US extreme-risk pivotal trial described outcomes of TAVI using the self-expandable (SE) Medtronic CoreValve (Medtronic Inc., Minneapolis, MN, USA) in inoperable patients and demonstrated the efficacy of this treatment option with a 40% reduction in the one-year combined endpoint of all-cause mortality and stroke.13 The randomised CoreValve US high-risk pivotal trial compared the same device with SAVR in patients deemed to be of high surgical risk. For the first time, TAVI was shown to be associated with a mortality benefit (14.2 vs 19.1%; p<0.0001 for non-inferiority and p = 0.04 for superiority).

Current guidelines

Based on current trial and registry data, recommendations by both the European Society of Cardiology (ESC) and the American Heart Association/American College of Cardiology support the role of TAVI in the treatment of severe symptomatic AS in patients deemed inoperable or of high surgical risk, and reaffirms the role of SAVR in all other patients.7,14 Current ESC guidelines are summarised in Table 1.

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Table 1.

Current ESC guidelines for TAVI.

It is important to emphasise that surgical risk is an important factor when deciding which treatment strategy is most suitable for an individual patient. Current guidelines advocate use of the EuroScore15 or Society of Thoracic Surgeons16 (STS) score (>20% or >10%, respectively, indicate that a patient is of high surgical risk). However, these scores have limitations and may not truly represent clinical status by omitting factors such as frailty that predict adverse outcomes.17 A number of frailty scores developed by specialist geratologists (eg McArthur study of successful ageing) are now being evaluated in conjunction with more established surgical risk scores to determine patient risk.

Central to the decision-making process in determining the optimal management strategy is the multidisciplinary ‘heart team’, comprised of interventional cardiologists, imaging cardiologists, cardiothoracic surgeons, cardiac anaesthetists and general physicians, who use information from clinical assessment, diagnostic work-up (see below) and their collective expertise to guide optimal treatment selection, procedural planning and post-operative care.18

Patient work-up

It is essential that all relevant information is obtained prior to deciding the best treatment strategy for an individual patient. Investigations can be carried out by the referring team or at the TAVI centre although results must be available to inform the heart team.

Confirmation of aortic stenosis

In the first instance, it is vitally important to confirm the baseline diagnosis of severe AS and be confident that this is the cause of the presenting symptoms. Transthoracic echocardiography and transoesophageal echocardiography are most commonly used to confirm the presence of AS and its severity – current echocardiographic criteria are summarised in Table 2. Other imaging modalities, including computed tomography (CT) and magnetic resonance imaging (MRI) may have a supplementary role.

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Table 2.

Echocardiographic diagnostic criteria for severe aortic stenosis.

Anatomical assessment

Echocardiography and CT are routinely used in a complementary fashion for further anatomical assessment. In addition to the functional assessment of aortic stenosis, information concerning valve anatomy (presence of bicuspid valve), annular size, presence and distribution of valve calcium, relationship of the aortic valve to the left ventricular outflow tract and coronary ostia is essential in determining suitability for TAVI and device selection (Fig 1). Furthermore, assessment of ventricular function and exclusion of intracardiac thrombi are essential for procedural planning and risk assessment.

Fig 1.
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Fig 1.

CT of aortic annulus and arterial tree prior to TAVI. (a) Three-dimensional reconstruction of vasculature, demonstrating calcification (arrows) and tortuosity of peripheral vessels. (b) Two-dimensional assessment demonstrating calcification (white arrows) of trileaflet aortic valve, (c) position of right and (d) left coronary ostia. (e) Visualisation of aortic annulus (white line) used in annular sizing and device selection. CT = computed tomography; TAVI = transcatheter aortic valve implantation.

Access site

Transfemoral access has a number of advantages, including shorter procedure times, ability to use sedation (and not general anaesthesia) and shorter recovery times, and is now the default route for TAVI. However, not all patients are suitable for this approach in view of the high prevalence of peripheral vascular disease in elderly patients with AS. CT and invasive angiography are both used to assess the peripheral vasculature (Fig 1A); current devices require a minimal luminal diameter >5.5 mm and the absence of significant calcification and tortuosity.

Coronary angiography

Patients routinely undergo coronary angiography to evaluate the presence and significance of concomitant coronary artery disease. While coronary artery bypass grafting is routinely carried out for significant coronary artery disease in the setting of SAVR, the benefit of this approach in the setting of TAVI is currently unclear.19 Current ongoing trials will provide evidence concerning the best treatment strategy in this patient group.

Blood tests

Baseline blood investigations should be carried out in all patients to exclude haematological disorders (eg anaemia, clotting abnormalities) and evaluate baseline renal and hepatic function.

Other investigations

Other routine investigations include pulmonary function tests (for anaesthetic assessment) and carotid ultrasound to determine stroke risk.

The procedure

Following heart team discussion and patient consent, patients are routinely admitted to hospital the day before their procedure to allow time to meet the medical, surgical and anaesthetic teams and ensure that there are no new medical issues that have arisen since initial assessment. Current guidelines strongly recommend that all TAVI procedures are performed with onsite cardiothoracic surgical support.7

Access site and anaesthesia

Use of the transfemoral route enables the procedure to be carried out under local anaesthesia/sedation in a cardiac catheterisation laboratory (although general anaesthesia is still frequently used in many centres). With development of vascular closure devices, this approach has now become completely percutaneous and no longer requires routine surgical ‘cut-down’ to access the femoral artery. Other more invasive vascular access sites (eg transapical, transaxillary and transaortic) require surgical expertise and general anaesthesia, and may be carried out in a hybrid operating theatre with radiological screening facilities or a cardiac catheterisation laboratory with appropriate specification to ensure procedural sterility.

Device selection

The majority of worldwide experience to date has been with the BE Edwards valves and SE Medtronic valves (Fig 2). In recent years, a number of advances in valve and delivery system design have significantly reduced complication rates (eg paravalvular leak, vascular injury and bleeding). Newer designs in early commercial phase also incorporate the ability to reposition or retrieve the valve if initial positioning is suboptimal.

Fig 2.
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Fig 2.

Implantation of balloon-expandable Edwards Sapien 3 valve and self-expanding Medtronic Evolut R valve. Edwards Sapien 3 valve: (a) appearance of valve; (b) representative patient with initial aortogram and temporary pacing wire in situ (white arrow); (c) valve is deployed under rapid pacing with inflation of balloon (yellow arrows) and deployment of valve (white arrow); (d) final fluoroscopic appearance of implanted valve; (e) final aortogram demonstrating functioning valve with no aortic regurgitation. Medtronic Evolut R valve; (f) appearance of valve; (g) representative patient with initial aortogram and temporary pacing wire in situ (white arrow); (h) valve is deployed without need for rapid pacing, with unsheathing of delivery system and self-expansion of valve (yellow arrows); (i) final fluoroscopic appearance of implanted valve (white arrow); (j) final aortogram demonstrating functioning valve with no aortic regurgitation.

All TAVI devices are deployed under fluoroscopic guidance (Fig 2) with frequent use of adjunctive echocardiography. Positioning of BE valves requires rapid ventricular pacing via a right ventricular temporary pacing wire to reduce aortic pressure and achieve cardiac standstill. This step is usually unnecessary for SE valves. Initial balloon aortic valvuloplasty is no longer routine, although post-dilatation may be required to optimise the result if there is significant paravalvular regurgitation following initial valve deployment.

Recovery and follow-up

Following the TAVI procedure, patients are usually admitted to a critical care ward for close haemodynamic monitoring and nursing care. According to the site of vascular access, mode of anaesthesia and overall clinical recovery, patients are then ‘stepped-down’ to a general ward to continue their recovery prior to discharge after 2–3 days. A pre-discharge transthoracic echocardiogram and echocardiography are mandatory to assess prosthetic valve function and exclude atrial fibrillation or new heart block, respectively.

The first clinical follow-up is usually undertaken by the TAVI team at 6–8 weeks to allow review of symptoms and clinical status, physical examination and echocardiography to assess valve function. In the absence of complications, annual follow-up thereafter by the local cardiology team is usually sufficient for patient convenience, providing that there is ready access to the TAVI team should problems arise.

During follow-up consultations, physicians should always be vigilant for signs and symptoms of valve failure. While acute causes (eg thrombosis or endocarditis) would warrant emergency transfer to the TAVI team for further management, the development of late prosthesis dysfunction requires medical therapy (eg initiation of diuretics for the management of heart failure) in the first instance and referral for evaluation of further treatment options. Patients more commonly present with general problems including new-onset atrial fibrillation or the development of heart failure requiring optimisation of medical therapy (eg antiplatelet therapy, anticoagulation and diuretics). Bearing in mind that the majority of patients that have been treated with TAVI suffer from many comorbidities, it is vitally important that secondary care teams work closely with medical and nursing teams in the community to ensure the best possible management of these complex patients.

Current limitations

In spite of increasing operator experience and rapid advances in valve and delivery system design, there are a number of current issues that remain the focus of ongoing research to further improve clinical and procedural outcomes in this high-risk patient group.

Paravalvular leak

Registry and clinical trial data (eg the PARTNER trial12) have consistently identified moderate and severe paravalvular leak (PVL) as an independent predictor of early and late mortality following TAVI.8,12 PVL may arise as a result of poor apposition of the prosthesis with the aortic annulus due to the presence of calcium, an elliptically shaped annulus or undersized device, and appears to affect all devices (to a greater or lesser extent) irrespective of their mode of delivery. Detailed preprocedural imaging (eg the more frequent use of CT) and advances in prosthesis design ensure that PVL is now less frequent.20 The impact of these improvements on long-term clinical outcome is under assessment.

Conduction abnormalities

Conduction disturbances following TAVI are common (BE valves 7–18%, SE valves 30–83%).21 While permanent pacemaker implantation does not appear to adversely affect short or intermediate clinical outcomes,22 longer-term studies are required to assess the true impact of conduction abnormalities.

Stroke

Although only 2–4% of all patients suffer clinical signs or symptoms in keeping with a diagnosis of stroke within one year of their procedure, up to 80% of patients have evidence of cerebral injury when assessed by cerebral MRI following TAVI.23 A number of strategies are under investigation in an attempt to reduce the frequency of this important complication, including optimised antiplatelet or anticoagulant therapy, use of cerebral embolic protection devices, and reduced rates of pre- and post-deployment balloon valvuloplasty.

Cost

While the high cost of TAVI and need for accumulation of evidence to support safety and efficacy have appropriately limited widespread uptake, initial evidence from the PARTNER B trial demonstrated that initial higher costs of TAVI during index hospitalisation were more than offset by reduction in overall costs over the first year of follow-up. This has been attributed to a reduction in the need for repeat hospitalisation. In a more recent analysis, TAVI was more cost effective than SAVR in high-risk patients, particularly when performed via the less invasive transfemoral approach.24

Expanding indications

We have focused this manuscript on the treatment of patients with native AS, who form the majority of those considered for TAVI. However, indications have recently expanded significantly to encompass the treatment of bicuspid valves,25 aortic regurgitation26 and degenerating aortic and mitral bioprostheses.27 Long-term results concerning the efficacy of these procedures are awaited before adoption into routine clinical practice.

Future developments

The last few years have seen significant advances in TAVI technology. Coupled with greater operator experience and improved case selection, this has resulted in reduced rates of periprocedural complications and improved short- and medium-term outcomes. Indications have already expanded from the treatment of AS to other valve pathologies. Until now, use of TAVI has been limited to the treatment of inoperable and high-risk surgical patients, however, long-term outcome data concerning clinical outcomes and valve durability will determine whether TAVI should be used routinely for the treatment of lower risk populations. Ongoing trials, including PARTNER IIA, Surgical Replacement and Transcatheter Aortic Valve Implantation (SURTAVI)28 and UK TAVI29 will hopefully answer this question. Finally, continued refinement of case selection and device technology, coupled with shorter lengths of stay and falling device costs, will ensure that this revolutionary treatment becomes even more attractive to health funders.30

Conclusion

The prevalence of AS will continue to rise in the increasingly elderly population. TAVI is a revolutionary treatment for patients who previously would have been considered inoperable or high risk for conventional surgery. TAVI is now established for the treatment of these patients, and longer-term data concerning valve durability and clinical outcomes are eagerly awaited to ascertain whether TAVI should be routinely offered to lower risk populations. Outcomes and complication rates are set to improve further with accumulating operator experience and technological advances. Not only is TAVI here to stay, but it has also galvanised a revolution in the management of valvular heart disease, and encouraged a new collaborative approach to the management of complex cardiovascular disease.

Conflicts of interest

Dr Prendergast has received lecture fees from Edwards Lifesciences.

  • © Royal College of Physicians 2015. All rights reserved.

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Transcatheter aortic valve implantation – what the general physician needs to know
Neil Ruparelia, Bernard D Prendergast
Clinical Medicine Oct 2015, 15 (5) 420-425; DOI: 10.7861/clinmedicine.15-5-420

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Transcatheter aortic valve implantation – what the general physician needs to know
Neil Ruparelia, Bernard D Prendergast
Clinical Medicine Oct 2015, 15 (5) 420-425; DOI: 10.7861/clinmedicine.15-5-420
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