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Management of high-risk non-ST elevation myocardial infarction in the UK: need for alternative models of care to reduce length of stay and admission to angiography times

Sudheer Koganti and Roby D Rakhit
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DOI: https://doi.org/10.7861/clinmedicine.15-6-522
Clin Med December 2015
Sudheer Koganti
ADepartment of Cardiology, Royal Free Hospital, London, UK, and UCL Institute of Cardiovascular Science, London, UK
Roles: clinical research fellow
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Roby D Rakhit
BDepartment of Cardiology, Royal Free Hospital, London, UK, and UCL Institute of Cardiovascular Science, London, UK
Roles: consultant interventional cardiologist and honorary senior lecturer
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  • For correspondence: roby.rakhit@nhs.net
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    Fig 1.

    Current pathway for NSTE-ACS in the UK for DGH with angiogram only facilities. DGH = district general hospital; IHT = interhospital transfer; MAU = medical assessment unit; NSTE-ACS = non-ST elevation acute coronary syndrome; PCI = percutaneous coronary intervention.

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    Fig 2.

    Flowchart showing different pathways. A&E = accident and emergency; DGH = district general hospital; HAC-X = heart attack extension pathway; NSTE-ACS = non-ST elevation acute coronary syndrome.

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    Box 1.

    ESC recommendations for initial evaluation and angiography.7

    > An invasive strategy (within 72 h) after first presentation is indicated in patients with at least one high-risk criterion (Box 2) and or recurrent symptoms.
    > Urgent coronary angiography (<2 h) is recommended in patients at very high ischaemic risk (refractory angina, associated heart failure, life-threatening ventricular arrhythmias or haemodynamic instability).
    > An early invasive strategy (<24 h) is recommended with a GRACE score >140 or with at least one primary high-risk criterion.
    > Non-invasive documentation of inducible ischemia is recommended in low-risk patients without recurring symptoms before deciding for invasive evaluation.
    > Likewise routine invasive evaluation of low-risk groups is not recommended. However, if there is a secondary high-risk criterion (Box 2) present in low-risk subset with GRACE <140, invasive evaluation can be delayed but is recommended to be carried out during the same hospital stay or preferably within 72 h of admission.
    ESC = European Society of Cardiology; GRACE = Global Registry of Acute Coronary Events.
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    Box 2.

    High-risk criteria set out by ESC in the management and for evaluation of invasive angiography in patients presenting with NSTEMI.7

    Primary criteria:
    > relative rise or fall in troponin
    > dynamic ST-T wave changes (with or without symptoms)
    > GRACE score >140.
    Secondary criteria:
    > diabetes mellitus
    > renal insufficiency (eGFR <60 mL/min/1.73 m2)
    > early post-infarction angina
    > recent PCI
    > previous CABG
    > intermediate or high GRACE risk score.
    NB: This is different to the GRACE score (for GRACE score visit gracescore.co.uk). CABG = coronary artery bypass surgery; eGFR = estimated glomerular filtration rate; ESC = European Society of Cardiology; GRACE = Global Registry of Acute Coronary Events; PCI = percutaneous coronary intervention
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Management of high-risk non-ST elevation myocardial infarction in the UK: need for alternative models of care to reduce length of stay and admission to angiography times
Sudheer Koganti, Roby D Rakhit
Clinical Medicine Dec 2015, 15 (6) 522-525; DOI: 10.7861/clinmedicine.15-6-522

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Management of high-risk non-ST elevation myocardial infarction in the UK: need for alternative models of care to reduce length of stay and admission to angiography times
Sudheer Koganti, Roby D Rakhit
Clinical Medicine Dec 2015, 15 (6) 522-525; DOI: 10.7861/clinmedicine.15-6-522
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  • Article
    • ABSTRACT
    • Introduction
    • Epidemiology
    • Evidence behind current medical management of patients with NSTE-ACS
    • Current model of care for NSTE-ACS in the NHS
    • Role of facilitated pathways in treating patients with NSTE-ACS
    • Advantages of a direct access pathway
    • Limitations of fast-track pathways
    • Conclusion
    • References
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