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Psoriatic arthritis: state of the art review

Laura C Coates and Philip S Helliwell
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DOI: https://doi.org/10.7861/clinmedicine.17-1-65
Clin Med February 2017
Laura C Coates
ALeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK and Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Roles: NIHR clinical lecturer
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Philip S Helliwell
BLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK and Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Roles: senior lecturer
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  • For correspondence: p.helliwell@leeds.ac.uk
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    Fig 1.

    Typical ‘hidden’ psoriasis in peri-umbilical area (A), scalp (B), natal cleft (C) and nails (D).

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    Fig 2.

    Dactylitis in the hands (right second and fourth digits and left second digit) and feet (right third digit and left fourth digit).

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    Table 1.

    Differentiating rheumatoid arthritis (RA) and psoriatic arthritis (PsA)

    FeaturesPsARA
    Number of joints involved30–50% with oligoarthritisPredominant polyarthritis
    Joint involvementAny joint, including distal interphalangeal jointsUsually distal interphalangeal joint sparing
    EnthesitisTypical, clinically present in 60–80%Not typical
    DactylitisPresent in 30%Not typical
    Axial involvementAxial spondyloarthritis phenotypeErosive cervical disease
    Skin/nail diseasePsoriasis in 80%, nail disease in 60%Background population risk or lower
    SerologyUsually RF and CCP negativeUsually RF and/or CCP positive
    Typical radiographic changesPeriosteal new bone formation (uncommon especially in early disease)Erosion and osteopenia
    • CCP = cyclic citrullinated peptide; RF = rheumatoid factor

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    Table 2.

    The CASPAR criteria for classifying psoriatic arthritis

    Inflammatory articular disease (joint, spine or entheseal), with three or more points from the following:
    1. Evidence of psoriasis(a) Current psoriasis* orPsoriatic skin or scalp disease present today as judged by a rheumatologist or dermatologist
    (b) Personal history of psoriasis orA history of psoriasis that may be obtained from patient, family doctor, dermatologist, rheumatologist or other qualified healthcare provider
    (c) Family history of psoriasisA history of psoriasis in a first- or second-degree relative according to patient report
    2. Psoriatic nail dystrophy
    Typical psoriatic nail dystrophy including onycholysis, pitting and hyperkeratosis observed on current physical examination
    3. A negative test for rheumatoid factor
    By any method except latex but preferably by ELISA or nephelometry, according to the local laboratory reference range
    4. Dactylitis(a) Current orSwelling of an entire digit
    (b) HistoryA history of dactylitis recorded by a rheumatologist
    5. Radiological evidence of juxta-articular new bone formationIll-defined ossification near joint margins (but excluding osteophyte formation) on plain radiographs of hand or foot
    • *Current psoriasis scores 2 points. CASPAR = Classification Criteria for Psoriatic Arthritis; ELISA = enzyme-linked immunosorbent assay

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Psoriatic arthritis: state of the art review
Laura C Coates, Philip S Helliwell
Clinical Medicine Feb 2017, 17 (1) 65-70; DOI: 10.7861/clinmedicine.17-1-65

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Psoriatic arthritis: state of the art review
Laura C Coates, Philip S Helliwell
Clinical Medicine Feb 2017, 17 (1) 65-70; DOI: 10.7861/clinmedicine.17-1-65
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    • Why is it important to recognise PsA?
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  • Comparing the Visual Analog Scale and the Numerical Rating Scale in Patient-reported Outcomes in Psoriatic Arthritis
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  • Identification and Evaluation of Serum Protein Biomarkers Which Differentiate Psoriatic from Rheumatoid Arthritis
  • Imaging Techniques: Options for the Diagnosis and Monitoring of Treatment of Enthesitis in Psoriatic Arthritis
  • Evolution of psoriatic arthritis study patient population characteristics in the era of biological treatments
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