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Healthcare worker influenza vaccination and sickness absence – an ecological study

Miguel Pereira, Siân Williams, Louise Restrick, Paul Cullinan and Nicholas S Hopkinson on behalf of the London Respiratory Network
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DOI: https://doi.org/10.7861/clinmedicine.17-6-484
Clin Med December 2017
Miguel Pereira
ANational Heart and Lung Institute, London, UK
Roles: research fellow
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Siân Williams
BLondon Respiratory Network, London, UK
Roles: programme manager
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Louise Restrick
CLondon Respiratory Network and Whittington Health, London, UK
Roles: consultant chest physician
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Paul Cullinan
DNational Heart and Lung Institute, London, UK
Roles: professor of occupational and environmental respiratory disease
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Nicholas S Hopkinson
ELondon Respiratory Network and NIHR Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, UK
Roles: reader in respiratory medicine
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  • For correspondence: n.hopkinson@ic.ac.uk
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    Fig 1.

    Trends in influenza vaccine uptake across the 2011–12, 2012–13, 2013–14 and 2014–15 influenza seasons. Results represented for each type of healthcare worker (HCW): doctors, nurses, other HCWs and non-clinical support staff.

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    Table 1.

    Absolute number of healthcare workers per influenza season

    Flu season
    2011–122012–132013–142014–15
    Total staff802,710811,654821,214830,611
     Doctors95,251 (11.9%)101,394 (12.5%)101,639 (12.4%)102,849 (12.4%)
     Nurses314,652 (39.2%)307,449 (37.9%)315,622 (38.4%)321,365 (38.7%)
     Other clinical staff146,997 (18.3%)152,121 (18.7%)149,584 (18.2%)148,939 (17.9%)
     Non-clinical support staff245,810 (30.6%)250,690 (30.9%)254,369 (31%)257,458 (31.0%)
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    Table 2.

    General sample characteristics by flu season (2011–12, 2012–13, 2013–14, 2014–15) in NHS trusts in England (n=223)

    Flu season
     2011–12 2012–13 2013–14 2014–15
    MeanSDMeanSDMeanSDMeanSD
    Sickness absence rate4.4670.8624.5920.9104.3760.8794.6350.951
    Flu vaccine uptake, %43.615.344.016.854.315.854.315.6
     Doctors45.122.043.422.353.821.053.223.2
     Nurses38.517.139.018.048.018.147.717.4
     Other clinical staff49.420.649.820.659.119.658.618.9
     Non-clinical support staff49.423.150.624.860.123.060.922.7
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    Table 3.

    Association between influenza vaccine uptake and sickness absence rate adjusted for flu vaccine efficacy, flu deaths in England, type of NHS trust and Overall Engagement Score obtained from the NHS staff survey

    Beta95% CIp-value
    Influenza vaccine uptake–0.425(–0.658 to –0.192)<0.001
    Influenza vaccine efficacy–0.008(–0.010 to –0.006)<0.001
    Influenza deaths0.004(–0.001 to 0.000)<0.001
    Overall engagement score (NHS staff survey)–1.039(–1.399 to –0.679)<0.001
    Intercept9.004(7.623 to 10.384)<0.001
    • Results correspond to a linear mixed-effects models with a random intercept for NHS trust

    • View popup
    Table 4.

    Association between influenza vaccine uptake in each class of healthcare worker and sickness absence rate

    Beta95% CIp-valueAdjusted p-value*
    Doctors–0.218(–0.385 to –0.051)0.0110.014
    Nurses–0.378(–0.598 to –0.159)0.0010.004
    Other clinical staff–0.202(–0.364 to –0.039)0.0150.015
    Non-clinical support staff–0.232(–0.381 to –0.083)0.0020.004
    • *p-values adjusted for multiple testing using the Benjamini-Hochberg method.

    • Results correspond to a linear mixed-effects model with a random intercept for NHS trust for each class separately. Each model was adjusted for flu vaccine efficacy, flu deaths in England, type of NHS trust and Overall Engagement Score obtained from the NHS staff survey.

    • View popup
    Table 5.

    Sensitivity analysis – association between influenza vaccine uptake in each class of healthcare worker and sickness absence rate in the months outside of the flu season (April to September)

    Beta95% CIp-value
    Influenza vaccine uptake0.212(0.004 to 0.421)0.046
    Influenza vaccine efficacy–0.003(–0.005 to –0.001)0.001
    Influenza deaths0.0002(0.0001 to 0.0004)0.002
    Overall engagement score (NHS staff survey)–1.203(–1.526 to –0.879)<0.001
    Intercept8.530(7.291 to 9.770)<0.001
    • View popup
    Table 6.

    Sensitivity analysis – association between influenza vaccine uptake in each class of healthcare worker and sickness absence rate in the months outside of the flu season (April to September)

    Beta95% CIp-valueAdjusted p-value*
    Doctors0.175(0.026, 0.324)0.0210.084
    Nurses0.040(–0.157, 0.237)0.6890.925
    Other clinical staff0.053(–0.091, 0.199)0.4660.925
    Non-clinical support staff0.001(–0.127, 0.083)0.9250.925
    • *p-values adjusted for multiple testing using the Benjamini-Hochberg method

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Healthcare worker influenza vaccination and sickness absence – an ecological study
Miguel Pereira, Siân Williams, Louise Restrick, Paul Cullinan, Nicholas S Hopkinson
Clinical Medicine Dec 2017, 17 (6) 484-489; DOI: 10.7861/clinmedicine.17-6-484

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Healthcare worker influenza vaccination and sickness absence – an ecological study
Miguel Pereira, Siân Williams, Louise Restrick, Paul Cullinan, Nicholas S Hopkinson
Clinical Medicine Dec 2017, 17 (6) 484-489; DOI: 10.7861/clinmedicine.17-6-484
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