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- Fig 1.
The key pathophysiological changes of sepsis and how these combine to produce multiorgan failure.
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Respiratory rate ≥22/min Glasgow Coma Scale <15 Systolic blood pressure ≤100 mmHg > A need for vasopressor therapy to maintain a mean arterial pressure ≥65 mmHg > A serum lactate >2 mM, persisting after adequate fluid resuscitation Origin Website Focus Sepsis Trust https://sepsistrust.org/education/clinical-tools/ UK-based charity and originator of the ‘Sepsis six’ Produced in collaboration with NICE National Institute for Health and Care Excellence (NICE) guidelines www.nice.org.uk/guidance/ng51 Comprehensive though complex algorithms Published before new sepsis definitions Royal College of Physicians www.rcplondon.ac.uk/guidelines-policy/acute-care-toolkit-9-sepsis Distillation of NICE guidance and again uses older definitions Royal College of Emergency Medicine www.rcem.ac.uk/docs/Clinical%20Standards%20and%20Guidance/Clinical%20Standards%20for%20Emergency%20Departments.pdf Based on Sepsis Trust guidelines Tailored to emergency department use Surviving sepsis campaign www.survivingsepsis.org/Bundles/Pages/default.aspx The most up to date and useful of the guidelines, using the new (2016) definitions of sepsis
