Assessment of acute headache in adults – what the general physician needs to know

ABSTRACT
Headache is common. Up to 5% of attendances to emergency departments and acute medical units are due to headache. Headache is classified as either primary (eg migraine, cluster headache) or secondary to another cause (eg meningitis, subarachnoid haemorrhage). Even in the acute setting the majority of cases are due to primary causes. The role of the attending physician is to take a comprehensive history to diagnose and treat benign headache syndromes while ruling out sinister aetiologies. This brief article summarises the approach to assessment of headache presenting in acute and emergency care.
Key points
Diagnosis of headache in the acute setting depends primarily on the clinician taking a thorough history, supported by a focused examination
Primary headaches, especially migraine, are common in the acute setting – it is important to positively diagnose and treat these
Bacterial meningitis almost always presents with one of fever, neck stiffness and altered mental status in addition to headache
A thunderclap headache reaches maximum intensity within 60 seconds. In such cases, a CT scan of the brain and lumbar puncture are necessary to exclude subarachnoid haemorrhage
Medication overuse headache should be considered in anyone taking frequent analgesia for a primary headache disorder. Patients should be given advice on this condition
Fewer than 1 in 1,000 people under 50 years presenting with an isolated headache will have a brain tumour
Introduction
Headache is the commonest neurological symptom. 1–4% of emergency department (ED) attendances are due to headache, although only a small minority of these have a serious cause such as intracranial haemorrhage or meningitis.1,2
Headaches are classified as either primary or secondary.3 Primary headaches, such as migraine, have an independent pathophysiology with no other cause and are usually benign and recurrent. Secondary headaches are a symptom of another disorder. In all settings, including EDs, primary headache disorders are much commoner than secondary disorders.4
Assessment of headache in the acute setting
Management of headache in the acute setting should focus on excluding serious secondary causes, making a positive diagnosis, managing symptoms, and establishing a continuing care plan. Clinical assessment is based primarily on the history. A focused clinical examination helps exclude serious pathology. Investigations should be requested only where necessary. Imaging is not a substitute for robust clinical assessment.
Patients often find it difficult to describe their headache beyond its intensity and location. The clinician must ‘take the history’ and draw out the relevant features. The focus should be on the onset and evolution of symptoms. For example, patients may report a sudden severe headache, but this is not synonymous with the term ‘thunderclap headache’. The most useful initial question is ‘How long did the headache take to reach its maximum intensity?’ Table 1 lists other suggested questions. When considering associated features, specifically enquire about features of migraine, autonomic dysfunction and raised intracranial pressure. Broadly speaking, thunderclap headache and subacute progressive headache are more likely to be associated with secondary pathology, while recurrent episodic headache and chronic headache (>15 days a month for >3 months) are more likely to be due to a primary cause.
Useful questions
Examination should particularly assess for disturbance of vital signs, meningism, altered consciousness and obvious focal neurological deficit. Take particular care over ocular examination for ophthalmoplegia, ptosis, pupillary abnormalities and fundoscopy looking for papilloedema which are easily missed and may reflect serious pathology.
We will discuss serious secondary headache disorders which need to be excluded before turning to the primary headaches.
Secondary headaches
Many secondary causes of headache are clinically obvious (eg stroke or acute head trauma). Diagnostic difficulty arises primarily where headache is the only symptom, or one of only a few (Fig 1). The SNOOP4 mnemonic may be used to remember ‘red flags’ for serious secondary headaches (Table 2).5 These features and diagnoses should be carefully considered in all patients.
Some of the important secondary causes of acute headache.
SNOOP4 mnemonic to assess for secondary causes of headache
Bacterial meningitis
Acute bacterial meningitis presents with headache in 87% of cases, usually progressive over hours or days, and generalised. The classic triad of neck stiffness, fever and altered mental status is only present in 44% of cases.6 However, meningitis is very unlikely (<1%) in a patient with none of the triad.6 Be careful to distinguish neck stiffness from neck pain (present in 75% of migraineurs).7 Kernig's and Brudzinski's signs are well known but should not be relied upon (sensitivity is as low as 5%). Other features may include nausea, seizures, rash in meningococcal disease, and focal neurologic deficits.
If meningitis is suspected, take immediate blood cultures and give intravenous antibiotics and dexamethasone. As per recent UK guidelines,8 a computed tomography (CT) scan should not be performed as it delays lumbar puncture (LP) and treatment, except in suspected raised intracranial pressure with risk of brain shift (Table 3). Serum:CSF glucose ratio <0.36 is the most accurate laboratory predictor of bacterial meningitis.9 Management should follow established guidelines.8
Indications for neuroimaging before lumbar puncture in suspected bacterial meningitis
Thunderclap headache: subarachnoid haemorrhage and other vascular causes
Non-traumatic subarachnoid haemorrhage (SAH) is due to rupture of an intracranial aneurysm in >80% of cases, with a mortality of up to 50%.10 It only accounts for a small percentage of acute headaches seen in ED but must not be missed. Misdiagnosis quadruples the risk of death after 1 year.11
The classical presentation is of a ‘thunderclap’ headache (time to maximal intensity within 60 seconds). A ‘worst ever’ thunderclap headache, occurring on exertion is found in 70–85% of people with SAH and 3–10% of other new headaches in ED.12 Only 5% of SAH headaches resolve within 24 hours – the diagnosis is very unlikely when resolution occurs within 1 hour without treatment.13 However, resolution of headache with analgesia should not be taken to indicate a benign cause. The Ottawa SAH rule has been proposed to triage patients for investigation (Table 4).14
Ottawa subarachnoid haemorrhage rule for investigation of new non-traumatic severe headaches
Investigation of suspected SAH requires urgent brain CT imaging – sensitivity decreases with time. Non-contrast CT is reported to be >97% sensitive within 6 hours when interpreted by an experienced neuroradiologist. In routine practice, up to 20% of cases may be missed on multi-slice helical CT imaging within 6 hours.15 Therefore, if the scan is negative, an LP must be performed >12 hours after headache onset for spectrophotometric assessment of xanthochromia.16 If LP is normal, then SAH is excluded up to 2 weeks after onset.17 Following diagnosis, CT or magnetic resonance (MR) angiography (CTA; MRA) is performed. If no aneurysm is found despite the presence of SAH, then catheter angiography remains the gold standard.16 CTA should not be used for diagnosis as ∼3% of the population have an intracranial aneurysm.18
Only 11–25% of thunderclap headaches are due to SAH. The differential diagnosis includes other vascular headaches. Carotid artery dissection (particularly suggested by preceding neck trauma, or Horner's syndrome) and vertebrobasilar dissection (occipital or neck pain and nausea or vertigo) may present with acute headache,19 often before the onset of subsequent stroke. Diagnosis is by CT/MR/catheter angiography.
Cerebral venous sinus thrombosis particularly affects women, especially in pregnancy and peripartum. Headache is present in 90%, often as the first symptom, and is often gradual but may be ‘thunderclap’ in 10%. Features of raised intracranial pressure may occur, as may seizures (40%) and focal neurologic deficits (20%).20 Diagnosis is by CT/MR venography.
Reversible cerebral vasoconstriction syndrome (RCVS) is an increasingly recognised, although poorly understood, disorder. It is usually characterised by recurrent thunderclap headaches associated with reversible constriction of cerebral arteries. There may be an identifiable trigger event. The thunderclap headaches occur several times over weeks, with each episode lasting just minutes to hours, in contrast to SAH.21 Strokes and seizures, although unusual, sometimes occur. Initial brain imaging is often normal. Diagnosis is confirmed by angiography and treatment is supportive.
Other causes of thunderclap headache with normal routine imaging include pituitary apoplexy, hypertensive encephalopathy and spontaneous intracranial hypotension.
Other serious secondary headaches
Giant cell arteritis (GCA) should be considered in all adults >50 years of age with new chronic headache, especially if there is systemic malaise. Headache in GCA is only infrequently temporal.22 Scalp tenderness is not specific and occurs in many headaches, including migraine. Jaw and tongue claudication are specific but occur in < 50%. Full blood count (FBC), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) should be performed. If suspected, start high dose steroids and arrange confirmatory temporal artery biopsy later.
Up to 6% of ED attendees with headache may have carbon monoxide toxicity.23 A high index of suspicion is needed. Toxicity causes non-specific headache, dizziness, nausea and confusion. ‘Cherry red’ skin and lip discoloration are rare.24 Blood gas measurement of carboxyhaemoglobin is confirmatory. Treatment is with 100% high-flow oxygen.24
Acute angle-closure glaucoma may present, particularly in the elderly, primarily as frontal headache with nausea and halo-like visual phenomena. It is thus sometimes misdiagnosed as migraine.25 The pupil may be fixed or irregular with conjunctival injection.25 If suspected, intraocular pressure measurement is diagnostic.
Although headaches occur in >50% of adults with malignant brain tumours,26 they are the sole presenting symptom in just 2%.27 Conversely, 0.08% of adults under 50 years with a new headache will have a tumour, rising to 0.28% over 50 years.26 Most patients also have seizures, focal neurologic deficits or altered mental status.27 Headache characteristics are variable, but may manifest raised pressure features. Fundoscopy to exclude papilloedema is therefore mandatory in all chronic headache patients. In obese, young women with raised increased intracranial pressure (ICP) headache and papilloedema with normal imaging, consider idiopathic intracranial hypertension (venous sinus thrombosis should first be excluded in this context).
Primary headaches
‘Headache’ is a symptom, not a diagnosis. Where there is no clinically suspected secondary headache, a primary headache diagnosis should be sought and actively managed. The most prevalent primary headaches are migraine (∼15%), tension type headache (∼60%) and cluster headache (∼0.1%).
Migraine is one of the top 10 causes of disability worldwide28 with 8–14% of sufferers presenting to ED at some time. It is characterised by photophobia, phonophobia, osmophobia and motion intolerance, with moderate to severe throbbing pain and nausea and/or vomiting.3 However, these distinguishing features may diminish when symptoms become chronic, leaving unremitting pain and high disability. Only one-third of patients experience aura.29 In practice, most episodic, recurrent disabling headache is due to migraine.
Migraine is under-reported by patients and under-diagnosed. Effective acute treatment of episodic migraine reduces the risk of progression to chronic migraine.30 Initial management in ED may be with combination therapy of a triptan and high-dose NSAID (eg 900 mg aspirin or 500 mg naproxen).31 Dopamine antagonist antiemetics (domperidone or metoclopramide) can be used with analgesia and have an independent action on acute migraine and migraine-associated gastroparesis. Opiates should be avoided. Establish follow-up with primary care or neurology services for consideration of longer-term prophylaxis.32
By contrast, tension-type headache (TTH) is a featureless bilateral headache which is not disabling acutely. This is rarely the diagnosis in ED patients. When suspected, further elaboration of the history typically reveals the diagnosis to be migraine.
Cluster headache manifests as excruciating, strictly unilateral headache with prominent ipsilateral autonomic dysfunction. Migraine is unilateral in 60% of cases,29 and may also show autonomic disturbance. However, cluster attacks typically last 30 minutes to, at most, 4 hours, while untreated migraine in adults lasts >4 hours and sometimes days. Moreover, patients with cluster headache are typically very restless while migraineurs are motion intolerant. Acute treatment is with sumatriptan 6 mg subcutaneous injections or 100% oxygen delivered through a non-rebreathing face mask. Standard analgesics (including oral triptans) are rarely effective. A tapering course of high-dose prednisolone may be initiated. Verapamil is the first line prophylactic but should be initiated under specialist guidance.33
Medication overuse headache
Medication overuse headache (MOH) is a common complication of primary headache disorders (prevalence is 1%), leading to chronic headache.3 It is diagnosed when medications such as triptans, opioids and combination analgesics are used on >10 days/month or NSAIDs or paracetamol on >15 days/month. MOH resembles the underlying primary headache type, but is refractory to preventative medications until analgesic overuse is rectified. The number of days a painkiller is used is more important than the overall dose taken per day.
Following diagnosis of a primary headache disorder in the acute setting establish continuity of care to help prevent re-presentation. Encourage the patient to keep a headache diary including frequency, duration and timing of attacks. Patients with migraine or TTH should be warned explicitly about prevention of MOH.
Further reading
UK guidelines on management of headache are available from NICE.31 We particularly recommend the detailed guidelines on the management of primary headaches available online from the British Association for the Study of Headache.32
- © Royal College of Physicians 2018. All rights reserved.
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