From genomics to targeted treatment in haematological malignancies: a focus on acute myeloid leukaemia
Niels Asger Jakobsen and Paresh Vyas
DOI: https://doi.org/10.7861/clinmedicine.18-2-s47
Clin Med April 2018 Niels Asger Jakobsen
AWeatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
Roles: clinical research fellow
Paresh Vyas
BMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK and Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Roles: professor of haematology
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vol. 18 no. Suppl 2 s47-s53
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- Published online April 26, 2018.
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© Royal College of Physicians 2018. All rights reserved.
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- AWeatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- BMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK and Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
- Address for correspondence: Professor Paresh Vyas, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK. Email: paresh.vyas{at}imm.ox.ac.uk
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From genomics to targeted treatment in haematological malignancies: a focus on acute myeloid leukaemia
Niels Asger Jakobsen, Paresh Vyas
Clinical Medicine Apr 2018, 18 (Suppl 2) s47-s53; DOI: 10.7861/clinmedicine.18-2-s47
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- ABSTRACT
- Introduction
- From morphological towards genomic classification of disease
- Targeting signalling pathways
- Differentiation therapy
- Immunotherapy
- Antibody-drug conjugates
- Bispecific T-cell engaging antibodies
- Immune-checkpoint inhibitors
- Adoptive T-cell therapy
- Conclusions
- Conflicts of interest
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