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Posterior reversible encephalopathy syndrome

Linpei Jia and Hongliang Zhang
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DOI: https://doi.org/10.7861/clinmed.Let.20.3.1
Clin Med May 2020
Linpei Jia
Xuanwu Hospital, Beijing, China
Roles: Resident doctor
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Hongliang Zhang
National Natural Science Foundation of China, Beijing, China
Roles: Programme director in neuroscience and psychology
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Editor – Tan and Tan reported a case of severe hypertension in which the patient had mild symptoms and normal neurological examination.1 Although interesting, we are concerned about the diagnosis of such a case.

Posterior reversible encephalopathy syndrome (PRES), also termed reversible posterior leukoencephalopathy syndrome, is a clinico-radiological diagnosis.2 The occurrence of PRES is related to autoregulation failure of cerebral blood circulation and/or endothelial dysfunction.2 Vasogenic oedema revealed by apparent diffusion coefficient (ADC) maps as increased signal intensity, preferably involving the posterior white matter, and reversible clinical manifestations like seizures, altogether contribute to the diagnosis of PRES.3 As mentioned in their abstract, ‘hypertensive encephalopathy (HE) is a subset of posterior reversible encephalopathy syndrome’.1 This appears problematic, as the latter should be a subset of the former. HE may occur with or without abnormal neuroimaging findings, the former of which may be diagnosed as PRES.

The 52-year-old man complained of worsening occipital headache and giddiness and denied weakness, blurring of vision or altered sensation. Neurological examination yielded no positive findings. In this regard, the diagnosis of encephalopathy is only supported by headache, giddiness and abnormal computed tomography (CT) findings. However, according to the National Institute of Neurological Diseases and Stroke, encephalopathy is a term for any diffuse disease of the brain that alters brain function or structure; the hallmark of encephalopathy is an altered mental state; depending on the type and severity of encephalopathy, common neurological symptoms are progressive loss of memory and cognitive ability, subtle personality changes, inability to concentrate, lethargy and progressive loss of consciousness.4 Global brain dysfunction is also referred to by the Nature Publishing Group.

Taken together, this is a case of severe hypertension with unidentified hypodense appearance in CT. The diagnosis of encephalopathy is not supported by the clinical manifestations. Magnetic resonance imaging is necessary for a reliable diagnosis.

  • © Royal College of Physicians 2020. All rights reserved.

References

  1. ↵
    1. Tan YY
    , Tan K. Hypertensive brainstem encephalopathy: a diagnosis often overlooked. Clin Med 2019;19:511–13.
    OpenUrlAbstract/FREE Full Text
  2. ↵
    1. Sharma M
    , Kupferman JC, Brosgol Y, et al. The effects of hypertension on the paediatric brain: a justifiable concern. Lancet Neurol 2010;9:933–40.
    OpenUrlCrossRefPubMed
  3. ↵
    1. Lee VH
    , Wijdicks EF, Manno EM, Rabinstein AA. Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol 2008;65:205–10.
    OpenUrlCrossRefPubMed
  4. ↵
    National Institute of Neurological Diseases and Stroke. Encephalopathy information page. NINDS, 2019. www.ninds.nih.gov/Disorders/All-Disorders/Encephalopathy-Information-Page
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Posterior reversible encephalopathy syndrome
Linpei Jia, Hongliang Zhang
Clinical Medicine May 2020, 20 (3) e46; DOI: 10.7861/clinmed.Let.20.3.1

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Posterior reversible encephalopathy syndrome
Linpei Jia, Hongliang Zhang
Clinical Medicine May 2020, 20 (3) e46; DOI: 10.7861/clinmed.Let.20.3.1
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