Abrupt deterioration and pulmonary embolism in COVID-19: a case report
ABSTRACT
A case is presented highlighting pulmonary embolism as an important complication of COVID-19 and the abruptness with which deterioration and widespread pulmonary infiltrates can develop even after relatively normal initial investigations, illustrating the importance of follow-up. The role of computed tomography in COVID-19 is also discussed.
Case report
A 52-year-old man attended the medical assessment unit with a 5-day history of dry cough, fever, and dyspnea. He had no pre-existing medical conditions. Investigations showed a normal full blood count, normal renal and liver biochemistry, normal troponin, normal clotting profile, and only mildly raised C-reactive protein (CRP). Arterial blood gas sampling including oxygenation was within normal range. A CXR and electrocardiograph were also normal. Same-day PCR nasopharyngeal swab detected severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA, confirming coronavirus disease-19 (COVID-19). As his symptoms were relatively mild and there were no high-risk comorbidities, he was discharged home with virtual clinic follow-up (daily telephone assessments).
Three days later he was significantly more breathless and was advised to re-attend – his oxygen saturation was now 83% on air. Computed tomography (CT) pulmonary angiography showed widespread bilateral ground-glass opacities consistent with extensive COVID-19 pneumonitis and substantial bilateral subsegmental pulmonary emboli (Fig 1; see also video at https://youtu.be/frh28BOkhtg). Blood tests now showed the typical COVID-19 profile with mild lymphopenia, mildly raised alanine aminotransferase and lactate dehydrogenase, modestly raised CRP, normal procalcitonin, raised ferritin and substantially raised D-dimer. He was treated with supportive care, high-flow oxygen, and direct oral anticoagulant; fortunately, he did not require mechanical ventilation or intensive care unit management. After 10 days he had recovered sufficiently to be discharged home.
Discussion
This case highlights the abruptness with which deterioration and widespread pulmonary infiltrates can develop in COVID-19 even after relatively normal initial investigations. It also highlights pulmonary embolic disease as an important complication, reported in up to 33% of cases.1,2 it is uncertain if the etiology is pulmonary thrombosis, thrombo-embolism or part of cytokine-storm-driven disseminated intravascular coagulation.2 Further studies are required to understand the pathophysiology behind this complication of COVID-19 and guide universally agreed anticoagulation policies.
Regarding the role of CT in COVID-19, professional societies have cautioned against its routine use as a first-line diagnostic test – because although highly sensitive, the CT features of COVID-19 pneumonia are not specific and also tend to peak later (day 6–11).3 Importantly, indiscriminate use of CT also places healthcare workers (eg technologists) at risk of exposure. Accordingly, most suspected COVID-19 patients are diagnosed on the basis of clinical assessment, CXR and blood tests while awaiting PCR results.
Nonetheless, with recognition of poor PCR sensitivity, many centres adopt the pragmatic approach of using CT in cases with the combination of high clinical suspicion, normal or indeterminate CXR, and negative PCR result, and in patients with marked deterioration in order to exclude occult pulmonary embolism.3 However, as decontamination and patient segregation protocols become more embedded in hospitals, the risk–benefit ratio may ultimately support wider diagnostic use. New CT technology and advances in post-processing may also support further application. For example, we highlight how simple 3D-volume rendering and semi-automated segmentation can provide a rapid visual map of inflammatory burden and the extent of disease, but this can be taken further: artificial intelligence methods have already been utilised to fully quantify opacity burden (facilitating response to treatment assessments) and distinguish findings in COVID-19 from community-acquired pneumonia or other lung disease. Such tools may prove indispensable in a prolonged pandemic or during a second wave.4
- © Royal College of Physicians 2020. All rights reserved.
References
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- Grillet F
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- Poissy J
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- Tavare AN
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- Kundu S
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