Skip to main content

Main menu

  • Home
  • Our journals
    • Clinical Medicine
    • Future Healthcare Journal
  • Subject collections
  • About the RCP
  • Contact us

Clinical Medicine Journal

  • ClinMed Home
  • Content
    • Current
    • Ahead of print
    • Archive
  • Author guidance
    • Instructions for authors
    • Submit online
  • About ClinMed
    • Scope
    • Editorial board
    • Policies
    • Information for reviewers
    • Advertising

User menu

  • Log in

Search

  • Advanced search
RCP Journals
Home
  • Log in
  • Home
  • Our journals
    • Clinical Medicine
    • Future Healthcare Journal
  • Subject collections
  • About the RCP
  • Contact us
Advanced

Clinical Medicine Journal

clinmedicine Logo
  • ClinMed Home
  • Content
    • Current
    • Ahead of print
    • Archive
  • Author guidance
    • Instructions for authors
    • Submit online
  • About ClinMed
    • Scope
    • Editorial board
    • Policies
    • Information for reviewers
    • Advertising

The placebo effect of direct current cardioversion on atrial fibrillation: myth or fact

Myat Kaung Thu and Sanjay Gupta
Download PDF
DOI: https://doi.org/10.7861/clinmed.20-2-s61
Clin Med March 2020
Myat Kaung Thu
AYork Teaching Hospital NHS Foundation Trust, York, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sanjay Gupta
AYork Teaching Hospital NHS Foundation Trust, York, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
Loading

Introduction

Atrial fibrillation (AF) is the most common type of arrhythmia across the world, with an estimated prevalence of 2% in the UK population.1 Therapeutic strategies such as medications and AF ablation are used to achieve symptomatic improvement in patients with AF. In our clinical practice, a significant number of patients report symptomatic improvement after direct current (DC) cardioversion. It is as yet unclear as to how much of the purported benefit is due to just a placebo effect. This project aimed to identify the perceived placebo effect of DC cardioversion.

Methods

A retrospective observational study has been undertaken locally by examining case notes from 100 patients who underwent DC cardioversion from February 2016 to March 2017, which included follow-up data for 24 months.

Results

Eighty-three AF patients and 17 atrial flutter patients were involved in this project (Table 1). Rate control had been achieved before DC cardioversion in all patients. These patients were prescribed anticoagulant (direct oral anticoagulant (DOAC) or warfarin) for at least 4 weeks before DC cardioversion. AF related symptoms were assessed at the follow-up clinic following DC cardioversion. Based on the reported symptoms, we collected and analysed symptoms as written in the clinic letter then categorised these into two different groups; improved or not improved. Two patients died and one patient did not attend for follow up. The data for 10 patients did not clearly state the patient symptoms or were not available due to not following up in the clinic letter.

View this table:
  • View inline
  • View popup
Table 1.

Summary of results

Following DC cardioversion, 48 patients (48%) achieved sinus rhythm whereas 49 patients (49%) remained in arrhythmia (AF or flutter) at the 24-month follow-up point.

In the sinus rhythm group, 38 patients (79.6%) reported symptom improvement in relation to the AF-related symptoms. Surprisingly, in the other group, a group of patients who were still reverted to AF, 16 patients (32.65%) mentioned improved AF-related symptoms following DC cardioversion.

Conclusions

Although this study is a subjective and retrospective project, it highlighted that DC cardioversion has a positive impact on patient symptoms, whether rhythm control is achieved or not. By offering DC cardioversion, there will be nearly 50% chance of getting back to sinus rhythm at the 24-month follow up. It is expected to improve clinical symptoms in four out of five people in whom sinus rhythm is achieved. Even if they revert back to AF or flutter, one in three patients have improved symptoms following DC cardioversion. These findings may be useful in the management of patients suffering from AF-related symptoms who have already achieved rate control.

Conflicts of interest

None declared.

  • © Royal College of Physicians 2020. All rights reserved.

Reference

  1. ↵
    1. Hobbs FD
    , Fitzmaurice DA. A randomised controlled trial and cost-effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in people aged 65 and over. The SAFE study. Health Technol Assess 2005;9:174.
    OpenUrl
Back to top
Previous articleNext article

Article Tools

Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
The placebo effect of direct current cardioversion on atrial fibrillation: myth or fact
Myat Kaung Thu, Sanjay Gupta
Clinical Medicine Mar 2020, 20 (Suppl 2) s61; DOI: 10.7861/clinmed.20-2-s61

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The placebo effect of direct current cardioversion on atrial fibrillation: myth or fact
Myat Kaung Thu, Sanjay Gupta
Clinical Medicine Mar 2020, 20 (Suppl 2) s61; DOI: 10.7861/clinmed.20-2-s61
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Introduction
    • Methods
    • Results
    • Conclusions
    • Conflicts of interest
    • Reference
  • Figures & Data
  • Info & Metrics

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • An experimental series investigating the factors that influence the effect of hyperinsulinaemic euglycaemia on myocardial blood flow reserve
  • Specialist emergency care and COPD outcomes
  • A multi cross-site survey on Trichomonas vaginalis diagnosis in the Barts Health NHS Trust, London
Show more Clinical

Similar Articles

Navigate this Journal

  • Journal Home
  • Current Issue
  • Ahead of Print
  • Archive

Related Links

  • ClinMed - Home
  • FHJ - Home
clinmedicine Footer Logo
  • Home
  • Journals
  • Contact us
  • Advertise
HighWire Press, Inc.

Follow Us:

  • Follow HighWire Origins on Twitter
  • Visit HighWire Origins on Facebook

Copyright © 2021 by the Royal College of Physicians