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Diabetic retinopathy for the non-ophthalmologist

Timothy HM Fung, Bakula Patel, Emma G Wilmot and Winfried MK Amoaku
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DOI: https://doi.org/10.7861/clinmed.2021-0792
Clin Med March 2022
Timothy HM Fung
ASt Thomas’ Hospital, London, UK
Roles: senior fellow in vitreoretinal surgery
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  • For correspondence: timothyfung@doctors.org.uk
Bakula Patel
BUniversity of Nottingham School of Medicine, Nottingham, UK
Roles: general practitioner and clinical associate professor in primary care education
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Emma G Wilmot
CUniversity Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK
Roles: consultant diabetologist and honorary associate professor
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Winfried MK Amoaku
Dreader of clinical ophthalmology and honorary consultant ophthalmologist, Nottingham University Hospitals NHS Trust, Nottingham, UK
Roles: associate professor
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    Fig 1.

    Colour fundus photography of diabetic retinopathy lesions. a) A photograph of an eye with severe non-proliferative diabetic retinopathy showing dot (white arrowheads) and blot (white arrow) haemorrhages, exudates (black arrowheads) and intraretinal microvascular abnormalities (segments of dilated and tortuous retinal vasculature amid retinal vessels; black arrow). b) A close-up photograph of an eye with diabetic macular oedema showing exudates (black arrows) and microaneurysms (white arrows) at the macula, a cotton wool spot is shown just outside the inferotemporal vascular arcade (white arrowhead).

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    Fig 2.

    Ultra-widefield fundus photography of an eye with active proliferative diabetic retinopathy showing laser photocoagulation scars (black arrows), new vessels elsewhere (white arrows) and a vitreous haemorrhage (white arrowheads).

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    Fig 3

    Ultra-widefield fundus photography of an eye with advanced proliferative diabetic retinopathy showing fibrovascular proliferations (white arrows), new vessels elsewhere (black arrowhead), subhyaloid haemorrhage (black arrow) and tractional retinal detachment (within area of the white arrowheads) involving the macula.

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    Table 1.

    Classification of diabetic retinopathy

    Diabetic retinopathy severity scaleFindings observable on dilated ophthalmoscopy
    No retinopathyNo abnormalities
    Mild non-proliferative diabetic retinopathyMicroaneurysms only
    Moderate non-proliferative diabetic retinopathyMore than just microaneurysms but less than severe non-proliferative diabetic retinopathy
    Severe non-proliferative diabetic retinopathyOne or more of the following, in the absence of proliferative diabetic retinopathy:
    • more than 20 intraretinal haemorrhages in each of four quadrants

    • definite venous beading in two or more quadrants

    • prominent intraretinal microvascular abnormalities in one or more quadrants

    Proliferative diabetic retinopathyOne or more of the following:
    • extraretinal neovascularisation (NVD or NVE)

    • vitreous or preretinal haemorrhage

    Mild diabetic macular oedemaSome retinal thickening or hard exudates in posterior pole but distant from the centre of the macula
    Moderate diabetic macular oedemaRetinal thickening or hard exudates approaching the centre of the macula but not involving the centre
    Severe diabetic macular oedemaRetinal thickening or hard exudates involving the centre of the macula
    • Adapted from the proposed international diabetic retinopathy and diabetic macular oedema disease severity scales.9 NVD = neovascularisation at the disc; NVE = neovascularisation of the retina elsewhere.

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Diabetic retinopathy for the non-ophthalmologist
Timothy HM Fung, Bakula Patel, Emma G Wilmot, Winfried MK Amoaku
Clinical Medicine Mar 2022, 22 (2) 112-116; DOI: 10.7861/clinmed.2021-0792

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Diabetic retinopathy for the non-ophthalmologist
Timothy HM Fung, Bakula Patel, Emma G Wilmot, Winfried MK Amoaku
Clinical Medicine Mar 2022, 22 (2) 112-116; DOI: 10.7861/clinmed.2021-0792
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  • Article
    • ABSTRACT
    • Key points
    • Introduction
    • Who gets diabetic retinopathy?
    • How is diabetic retinopathy classified?
    • What is the natural course of diabetic retinopathy?
    • What are the symptoms of diabetic retinopathy?
    • How is diabetic retinopathy assessed and diagnosed?
    • What are the principles of diabetic retinopathy management?
    • Prevention
    • Early detection
    • Ophthalmological treatments
    • What new ophthalmological treatments can we expect for DR?
    • Conflicts of interest
    • References
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