Article Figures & Data
Figures
- Fig 1.
Receiver operating characteristic curve for the ability of blood loss to discriminate between patients with and without postoperative thrombosis. AUC = area under the curve.
- Fig 2.
Receiver operating characteristic curve for the multivariable prognostic model with the independent factors. AUC = area under the curve.
- Fig 3.
Postoperative prognostic nomogram to predict the probability of postoperative thrombosis after liver transplantation.
- Fig 4.
Calibration curve of the nomogram for the probability of postoperative thrombosis (bootstrap 1,000 repetitions). C-index = concordance index; CI = confidence interval.
- Fig 5.
Receiver operating characteristic curves for predicting postoperative thrombosis. a) Primary cohort. b) Validation cohort. AUC = area under the curve; CI = confidence interval.
Tables
Total, n=232 No thrombosis, n=206 With thrombosis, n=26 p-value Blood loss, mL/kg, median (IQR) 16.9 (10.1–28.9) 15.9 (9.8–27.9) 32.8 (17.9–61.5) <0.001 IQR = interquartile range.
Total, n=232 No thrombosis, n=206 With thrombosis, n=26 p-value MELD score, median (IQR) 15 (10–20) 15 (10–19) 18 (12–26.5) 0.056 Primary hepatic carcinoma, n (%) 73 (31.5) 69 (33.5) 4 (15.4) 0.061 Hemoglobin, g/L, mean (SD) 109.3 (24.4) 111 (24) 96.4 (23.9) 0.007 RBC count, × 1012/L, median (IQR) 3.5 (3–4.1) 3.5 (3.0–4.2) 3.1 (2.6–3.5) 0.017 Haematocrit, %, median (IQR) 32 (27.9–37.5) 32.4 (28.2–38.1) 28.3 (23.8–33) 0.006 PT, seconds, median (IQR) 17.7 (15.7–20.9) 17.6 (15.5–20.5) 19.6 (17.1–27.8) 0.004 aPTT, seconds, median (IQR) 44.8 (40.2–51.4) 44.4 (39.9–50.4) 48.3 (42.5–58.1) 0.031 INR, median (IQR) 1.5 (1.3–1.8) 1.5 (1.2–1.8) 1.7 (1.4–2.6) 0.004 Fibrinogen, g/L, median (IQR) 1.8 (1.5–2.4) 1.8 (1.5–2.4) 1.6 (1–2) 0.008 D-dimer, mg/L, median (IQR) 1.8 (0.8–4.3) 1.7 (0.7–4.1) 3.6 (1.3–10.1) 0.004 aPTT = activated partial thromboplastin time; INR = international normalised ratio; MELD = Model for End-stage Liver Disease; PT = prothrombin time; RBC = red blood cell.
Total, n = 232 No thrombosis, n = 206 With thrombosis, n = 26 p-value Duration of surgery, hours, median (IQR) 6 (5.5–7) 6 (5.5–7) 7 (6–8.8) 0.003 Anhepatic phase, minutes, median (IQR) 50 (42–57) 51 (45–60) 51 (44–56) 0.391 HA anastomosis time, minutes, median (IQR) 40 (35–45) 40 (35–45) 40 (40–55) 0.096 Intraoperative blood transfusion RBC, mL/kg, median (IQR) 17.5 (8.1–26.2) 16.5 (7.4–25.3) 26 (18–40) 0.001 FFP, mL/kg, median (IQR) 18.2 (12.2–26.7) 16.7 (11.8–25.2) 27.7 (17.3–38.4) <0.001 Cryoprecipitate, units, median (IQR) 5 (0–10) 5 (0–10) 10 (0–17) 0.081 FFP = fresh frozen plasma; HA = hepatic artery; RBC = red blood cell.
p-value B SE Wald HR 95% CI Total blood loss ≥31.25 mL/kg 0.012 1.651 0.657 6.325 5.214 1.440–18.884 Haemoglobin, g/L 0.013 –0.156 0.063 6.193 1.856 1.757–1.967 Haematocrit, % 0.035 0.587 0.279 4.437 1.799 1.042–3.107 B = beta coefficient; CI = confidence interval; HR = hazard ratio; SE = standard error.
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