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Rapid echocardiography in the primary angioplasty era for timely detection and management of acute Stanford type A aortic dissection: a case illustration

Wai Yan K Nyunt-Thinn, Jahan Zaib, Nura Maiyadi and Kalaivani Mahadevan
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DOI: https://doi.org/10.7861/clinmed.22-4-s25
Clin Med July 2022
Wai Yan K Nyunt-Thinn
APortsmouth Hospitals University NHS Trust, Portsmouth, UK
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Jahan Zaib
APortsmouth Hospitals University NHS Trust, Portsmouth, UK
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Nura Maiyadi
APortsmouth Hospitals University NHS Trust, Portsmouth, UK
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Kalaivani Mahadevan
APortsmouth Hospitals University NHS Trust, Portsmouth, UK
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Introduction

Acute Stanford type A aortic dissection (ATAD), comprising two-thirds of all captured aortic dissections (AD) in the International Registry of Aortic Dissection (IRAD) series, is a life-threatening cardiothoracic emergency.1 Inpatient mortality without surgical intervention is approximately 50%–60%, reducing to 18% with timely operative management.2 Presentation is with cardiac chest pain (CCP) sometimes in conjunction with neurological, abdominal or peripheral vascular symptoms. Ischaemia on electrocardiography (ECG) and elevated troponin are often seen, precipitating initial management for acute coronary syndrome (ACS). We describe two cases of cardiac catheter lab (CCL) activation for presumed ST-elevation myocardial infarction (STEMI), where rapid echocardiography clinched diagnosis of ATAD and allowed timely transfer for life-saving surgical intervention.

Case 1

A previously fit 50-year-old man presented with CCP, inferolateral T-wave inversion and high-sensitivity troponin T of 646 ng/L. Treatment for ACS including dual-antiplatelet therapy was commenced. Ongoing chest pain, despite high-dose morphine, triggered repeat ECG, which demonstrated dynamic inferolateral ST elevation and led to CCL activation though bilateral blood pressures and transthoracic echocardiography (TTE) were also advised. These revealed a 30 mmHg blood pressure difference and a large dissection flap prolapsing into the ventricular outflow tract causing free aortic regurgitation (AR; Fig 1). Computed tomography (CT) of the aorta (Fig 2) was performed and the patient transferred directly to theatre at the regional cardiothoracic centre within 90 minutes of TTE diagnosis. He underwent aortic repair and mechanical aortic valve replacement (AVR).

Fig 1.
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Fig 1.

Aortic dissection detected by transthoracic echocardiography. a) Aortic root dissection flap. b) Colour flow showing severe aortic regurgitation jet. c) Dissection flap prolapsing into left ventricular outflow tract.

Fig 2.
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Fig 2.

Computed tomography showing type A aortic dissection. a) Dissection flap seen across the aortic arch, continuing into the descending aorta. b) Dissection flap seen in the aortic root intermittently compromising coronary ostium.

Case 2

A 69-year-old man with hypertension and hypercholesterolaemia, suffered severe CCP. Paramedic ECGs demonstrated widespread malignant ST-depression with ST-elevation in AVR, suggestive of critical left-main stem disease and triggering CCL activation. While preparing for emergent angiography in the CCL, revisitation of clinical history revealed symptoms of both transient visual disturbance at onset of chest pain and examination findings included a loud holodiastolic murmur. Rapid TTE was performed showing dilated aorta (5.8 cm) with mobile dissection flap intermittently compromising coronary ostia alongside free AR. Immediate onward transfer to cardiothoracic theatre occurred. At operation, dissection involvement of the left main ostium was observed, and treatment was with a 32 mm aortic interpositional graft.

Discussion

Annual incidence of AD is rare, reported at 4.4 per 100,000 person-years.3 Misdiagnosis of AD for ACS is unsurprising given the incidence of the latter is significantly higher, reported at 234 per 100,000 person-years.3 A recent study characterising aortic syndromes reported presence of aortic insufficiency and coronary ischaemia in 18.2% and 6.5% of all AD cases, respectively. Further, though CT was the primary modality of diagnosis (68.8%), echocardiography was successfully utilised in 16.9%.4 Study of TTE versus CT of the aorta for diagnosis of ATAD demonstrates accuracy, speed and ease of use of TTE and notes the value of additional information pertaining to complicating features of ATAD, such as aortic insufficiency and cardiac tamponade.5

Conclusion

Utilisation of rapid TTE in the CCL prior to emergent angiography in ACS presentations where clinical suspicion for AD is triggered, can allow early detection of ATAD, prevent detrimental coronary angiography and expedite appropriate life-saving operative interventions.

  • © Royal College of Physicians 2022. All rights reserved.

References

  1. ↵
    1. Hagan PG
    , Nienaber CA, Isselbacher EM, et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA 2000;283:897–903.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Evangelista A
    , Isselbacher EM, Bossone E, et al. Insights from the International Registry of Acute Aortic Dissection: A 20-Year experience of collaborative clinical research. Circulation 2018;137:1846–60.
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Nielson KM
    , Foldspang A, Larsen ML, et al. Estimating the incidence of the acute coronary syndrome: data from a Danish cohort of 138290 persons. Eur J Cardiovasc Prev Rehabil 2007;14:608–14.
    OpenUrl
  4. ↵
    1. DeMartino RR
    , Sen I, Huang Y, et al. Population-based assessment of the incidence of aortic dissection, intramural hematoma, and penetrating ulcer, and its associated mortality from 1995 to 2015. Circ Cardiovasc Qual Outcomes 2018;11:e004689.
    OpenUrl
  5. ↵
    1. Sobczyk D
    , Nycz K. Feasibility and accuracy of bedside transthoracic echocardiography in diagnosis of acute proximal aortic dissection. Cardiovas Ultrasound 2015;13:15.
    OpenUrl
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Rapid echocardiography in the primary angioplasty era for timely detection and management of acute Stanford type A aortic dissection: a case illustration
Wai Yan K Nyunt-Thinn, Jahan Zaib, Nura Maiyadi, Kalaivani Mahadevan
Clinical Medicine Jul 2022, 22 (Suppl 4) 25-26; DOI: 10.7861/clinmed.22-4-s25

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Rapid echocardiography in the primary angioplasty era for timely detection and management of acute Stanford type A aortic dissection: a case illustration
Wai Yan K Nyunt-Thinn, Jahan Zaib, Nura Maiyadi, Kalaivani Mahadevan
Clinical Medicine Jul 2022, 22 (Suppl 4) 25-26; DOI: 10.7861/clinmed.22-4-s25
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