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Purple urine bag syndrome

Ashwin Mohandas Pallath, Gayatri Gopan and Anoop TM
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DOI: https://doi.org/10.7861/clinmed.2023-0132
Clin Med May 2023
Ashwin Mohandas Pallath
ARegional Cancer Centre, Thiruvananthapuram, Kerala, India
Roles: senior resident
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Gayatri Gopan
ARegional Cancer Centre, Thiruvananthapuram, Kerala, India
Roles: senior resident
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Anoop TM
BRegional Cancer Centre, Thiruvananthapuram, Kerala, India
Roles: associate professor in medical oncology
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  • For correspondence: dranooptm@yahoo.co.in
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KEYWORDS
  • purple urine
  • Escherichia coli
  • proteus mirabilis
  • indwelling urinary catheters

A 70-year-old woman with lung cancer and brain metastases presented to the outpatient department with urine discolouration. She was incidentally found to have purple-coloured urine in her urinary bag (Fig 1). The patient had abdominal pain but did not have burning micturition, vomiting or chills. She also denied unusual dietary changes or any recent changes to her medication regimen. A urine culture yielded significant mixed growth of Escherichia coli and Proteus mirabilis. She was treated with antibiotics as per the sensitivity reports. She was counselled regarding the benign nature of this discoloration. She was advised to have catheter care on a regular basis.

Fig 1.
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Fig 1.

Patient with indwelling urinary catheter with purple-coloured urine in urinary bag.

Purple urinary bag syndrome (PUBS) was first reported by Barlow and Dickson in 1978.1 The microorganism most commonly associated with PUBS is E coli, followed by mixed bacterial growth.2 It is usually seen in patients with long-term indwelling urinary catheters.3 The pathogenesis is due to metabolism of tryptophan by bacteria in the gut to indole, which is later converted to indoxyl sulphate (indican) in the liver by hepatic conjugation. This is excreted and broken down in the urine by bacteria that have one or both of the enzymes phosphatase and sulfatase, which convert indican into indoxyl, which is then converted by oxidation in the urine to indirubin and indigo in an alkaline environment; the mixture of these two colours produces purple discoloration when it reacts with the plastic catheter bag.4 The management of PUBS mostly relies on identifying the underlying cause and treating it.

  • © Royal College of Physicians 2023. All rights reserved.

References

  1. ↵
    1. Barlow GB
    , Dickson JAS. Purple urine bags. Lancet 1978;311:220–1.
    OpenUrl
  2. ↵
    1. Saraireh M
    , Gharaibeh S, Araydah M, et al. Violet discoloration of urine: a case report and a literature review. Ann Med Surg 2021;68:102570.
    OpenUrl
  3. ↵
    1. Khan F
    , Chaudhry MA, Qureshi N, et al. Purple urine bag syndrome: an alarming hue? A brief review of the literature. Int J Nephrol 2011;1–3.
  4. ↵
    1. Kalsi DS
    , Ward J, Lee R, et al. Purple urine bag syndrome: a rare spot diagnosis. Dis Markers 2017;2017:9131872.
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Purple urine bag syndrome
Ashwin Mohandas Pallath, Gayatri Gopan, Anoop TM
Clinical Medicine May 2023, 23 (3) 270; DOI: 10.7861/clinmed.2023-0132

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Purple urine bag syndrome
Ashwin Mohandas Pallath, Gayatri Gopan, Anoop TM
Clinical Medicine May 2023, 23 (3) 270; DOI: 10.7861/clinmed.2023-0132
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