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The efficacy of low-dose radioactive iodine without a thionamide in the treatment of thyrotoxicosis

Mark Aitken, Ajith George, Charles Bodmer and John Cameron
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DOI: https://doi.org/10.7861/clinmedicine.3-3-265
Clin Med May 2003
Mark Aitken
∗Department of Endocrinology and Colchester General Hospital
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Ajith George
∗Department of Endocrinology and Colchester General Hospital
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Charles Bodmer
∗Department of Endocrinology and Colchester General Hospital
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John Cameron
∗Department of Endocrinology and Colchester General Hospital
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Abstract

Between 1999 and June 2001, 55 unselected thyrotoxic patients were prescribed 200 MBq radioactive iodine (131I). None of these patients received a thionamide such as carbimazole or propylthiouracil within two weeks of treatment or subsequently. Symptom relief was achieved using β blockers alone. Remission at one year was achieved in 84% of these patients and of these 62% were hypothyroid and taking thyroxine. Within this time, re-treatment of those who remained thyrotoxic achieved an overall success rate at one year of 95%. The outcome of 164 similar patients prescribed 250-400 MBq 131I between 1996 and 2001 gave comparable results. The failure rate after a single 200 MBq 131I dose was significantly lower than that previously published where 185 MBq 131I and thionamides had been used. Our low-dose strategy has the potential for halving the radiation exposure to the patient and the environment, when compared with the ablative strategies in common use.

  • radioiodine
  • thionamide
  • thyrotoxicosis
  • © 2003 Royal College of Physicians
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The efficacy of low-dose radioactive iodine without a thionamide in the treatment of thyrotoxicosis
Mark Aitken, Ajith George, Charles Bodmer, John Cameron
Clinical Medicine May 2003, 3 (3) 265-267; DOI: 10.7861/clinmedicine.3-3-265

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The efficacy of low-dose radioactive iodine without a thionamide in the treatment of thyrotoxicosis
Mark Aitken, Ajith George, Charles Bodmer, John Cameron
Clinical Medicine May 2003, 3 (3) 265-267; DOI: 10.7861/clinmedicine.3-3-265
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