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What is the place of thrombolysis in acute stroke? A review of the literature and a current perspective

Peter O Jenkins, Martin R Turner and Paul F Jenkins
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DOI: https://doi.org/10.7861/clinmedicine.8-3-253
Clin Med June 2008
Peter O Jenkins
Guys and St Thomas' Hospital, London
Roles: Foundation Year 1
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Martin R Turner
John Radcliffe Hospital, Oxford
Clinical Tutorial Fellow to Green College, Oxford
Roles: Specialist Registrar in Neurology
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Paul F Jenkins
University of Western Australia and Joondalup Health Campus, Perth, Australia
Roles: Professor of Medicine
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Abstract

The global burden of stroke, the undisputed success of intravenous thrombolysis in the management of myocardial infarction and subsequent evidence from animal models of cerebral infarction have all fuelled intense interest in the potential role for thrombolytic agents in the acute management of stroke in clinical practice. Before any clinical treatment is introduced universally its safety and efficacy must be demonstrated in the routine clinical environment and not just within the ideal conditions of controlled clinical trials. Similarly, the cost effectiveness of a new treatment modality is an essential consideration before its use is promulgated. This paper reviews the current scientific evidence for thrombolysis in stroke with reference to issues of safety, efficacy and cost effectiveness.

KEY WORDS
  • cerebral haemorrhage
  • cerebral infarction
  • cost effectiveness
  • stroke
  • thrombolysis
  • tissue plasminogen activator
  • © 2008 Royal College of Physicians
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What is the place of thrombolysis in acute stroke? A review of the literature and a current perspective
Peter O Jenkins, Martin R Turner, Paul F Jenkins
Clinical Medicine Jun 2008, 8 (3) 253-258; DOI: 10.7861/clinmedicine.8-3-253

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What is the place of thrombolysis in acute stroke? A review of the literature and a current perspective
Peter O Jenkins, Martin R Turner, Paul F Jenkins
Clinical Medicine Jun 2008, 8 (3) 253-258; DOI: 10.7861/clinmedicine.8-3-253
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