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Can the NICE guidelines on the management of atrial fibrillation improve its management?

Chee W Khoo and Gregory YH Lip
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DOI: https://doi.org/10.7861/clinmedicine.9-3-207
Clin Med June 2009
Chee W Khoo
University Department of Medicine, City Hospital, Birmingham
Roles: Research Fellow
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Gregory YH Lip
University Department of Medicine, City Hospital, Birmingham
Roles: Professor of Cardiovascular Medicine
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  • For correspondence: g.y.h.lip@bham.ac.uk
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Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia seen in clinical practice. The incidence of AF increases significantly with advancing age, with the prevalence being 8% for population of age 80 and above.1 For those who are 40 years and older, the lifetime risk for the development of AF is 1 in 4 in both men and women.2,3 With an ageing population, an increase in the incidence and prevalence of AF has been reported worldwide.4,5 Indeed, AF has become such a common problem that it is now described as ‘a major epidemic’.

Due to the close relationship between AF, stroke and thromboembolism there has been a need for increased caution. Irrespective of applying a rate-control or rhythm-control strategy thromboprophylaxis remains the essential core of any AF management strategy. Given that AF is so common various management guidelines have been published over the last few years.6,7 In the UK, the evidence-based national guidelines for the management of AF were published by the National Institute for Health and Clinical Excellence (NICE) in June 2006.7 The methodology for the NICE guidelines differs from other expert consensus-based guidelines in that, following agreement and definition of a scope for the NICE guideline, pertinent questions on AF management are formulated and a formal systematic review undertaken by an information scientist who would retrieve, assess and organise sources of published evidence. The latter is then critically appraised and graded by a health service research fellow and, if needed, a health economist. The synthesised evidence is reviewed and debated by a guideline development group (GDG), which included multidisciplinary representatives from various learned bodies and specialist organisations.

Despite the published guidelines for the management of AF, this common arrhythmia remains poorly managed, both in primary and secondary care, with marked variation in the approach to investigation and treatment. Apart from the specific recommendations, the NICE guidelines have highlighted five key priorities for implementation as well as audit criteria and areas for future research (Box 1). The remit of the NICE guideline on AF management was to provide a practical, pragmatic and highly applicable national guideline to the UK clinical setting, which would be applicable for >80% of AF patients for >80% of the time. Given this aim, has the publication of these guidelines actually improved AF management?

Box 1.

Priorities for implementation in the National Institute for Health and Clinical excellence guidelines for the management of atrial fibrillation (AF).

The following five recommendations have been identified as priorities for implementation:

  1. 1. An electrocardiogram should be performed in all patients, whether symptomatic or not, in whom AF is suspected because an irregular pulse has been detected.

  2. 2. As some patients with persistent AF will satisfy criteria for either an initial rate control or rhythm control strategy:

    • the indications for each option should not be regarded as mutually exclusive and the potential advantages and disadvantages of each strategy should be explained to patients before agreeing which to adopt

    • any comorbidities that might indicate one approach rather than the other should be taken into account

    • irrespective of whether a rate control or a rhythm control strategy is adopted in patients with persistent AF, appropriate antithrombotic therapy should be used.

  3. 3. In patients with permanent AF, who need treatment for rate control:

    • beta-blockers or rate-limiting calcium antagonists should be the preferred initial monotherapy in all patients

    • digoxin should only be considered as monotherapy in predominantly sedentary patients.

  4. 4. In patients with newly diagnosed AF for whom antithrombotic therapy is indicated, such treatment should be initiated with minimal delay after the appropriate management of comorbidities.

  5. 5. The stroke risk stratification algorithm should be used in patients with AF to assess their risk of stroke and thromboembolism, and appropriate thromboprophylaxis given.

In the current issue of Clinical Medicine, the paper by Loo and colleagues examines existing clinical practice in advance of publication of the NICE guidelines.8 Their study suggests that only 84% of 131 patients with diagnosis of AF had either electrocardiogram (ECG) documentation in primary and/or secondary care. Almost half of the patients with AF were managed in primary care alone and the diagnosis of AF was generally accurate. The use of echocardiography is an important part of management, and in the paper by Loo et al only 44% of the study population underwent an echocardiogram.8 However, this percentage increases in those who were diagnosed with AF after 2000 and those who had cardiology input from secondary care. This could probably be explained by a better understanding of the management of AF, better educational efforts and, perhaps, a better provision of echocardiography services from secondary care.

The overall rate of anticoagulation was higher than other studies, but there remains a discrepancy, with only about half of patients in the ‘high-risk’ group, according to NICE guidelines for thromboembolic risk, being prescribed warfarin.9,10 When comparing the NICE stroke risk score with the CHADS2 score, Loo and colleagues found that 50% of the patients recruited fell into the ‘high-risk’ category using the NICE schema, while only 28% of the same patients would be considered to be ‘high risk’ if the simpler CHADS2 scoring schema was used, despite the latter being published earlier (2001) than the NICE schema.8

Also, the large number of patients categorised in the intermediate/moderate-risk group by the CHADS2 schema reflects the limitation of the published stroke risk stratification schema in assisting clinicians’ antithrombotic therapy decision making. In the recent Stroke in AF working group analysis, the proportion classified as high risk could vary substantially – between 11% and 77% – depending on which schema was used.11 Given that current AF management guidelines recommend the use of either warfarin or aspirin in the intermediate-risk patient group, this potentially leads to the dilemma of whether anticoagulant therapy or aspirin should be used, and may create indecision for clinicians managing such patients.12 Also, the predictive value of various schema for stroke events is modest (C statistic values approximately 0.60–0.65) and efforts to improve this are clearly needed.13

To illustrate this issue, a cut-off point of age >75 is probably too simplistic, given that there is a relative risk for stroke of 1.5 per decade with increasing age, as documented by the AF working group.14 The recent Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) study, which considered patients with AF aged ≥75 years in the primary care setting, also showed that warfarin was significantly more effective than aspirin in preventing stroke (by over 50%, with nearly 2% annual absolute risk reduction), without any excess in the risk of major bleeding.15 Similarly, ‘hypertension’ as one of the criteria in the CHADS2 schema is ambigious, given that history of hypertension (but now well controlled) may well carry a different stroke risk to uncontrolled hypertension. In an analysis from the SPORTIF trial dataset, for example, there was a clear difference in stroke and systemic embolism with poorly controlled hypertension, compared to well-controlled blood pressure levels.16 Indeed, stroke events were low and fairly constant when mean systolic blood pressure was < 140 mmHg, but when levels exceeded this threshold, event rates for stroke and systemic embolism rose substantially.

Thus, there remains scope for better use of stroke risk stratification and improvements in the current schema to target stroke and thromboembolism prophylaxis appropriately, and a need for refinement of subjects classified at intermediate risk. Clearly, the article by Loo and colleagues illustrates that AF in general is still relatively poorly managed in primary and secondary care despite well-established principles and protocols.8

Can the NICE guidelines for the management of AF overcome this issue and ultimately improve patient care? Guidelines are simply recommendations for best practice given the best evidence available at the time. Indeed, new data mean that some recommendations in the NICE guidelines need to be revisited. For example, NICE suggest that rhythm control may be the best initial option for subjects with congestive heart failure. However, the AF–congestive heart failure trial recently reported that there was no significant difference in a rate control or rhythm control strategy for patients with AF and associated heart failure.17 Also, new antiarrhythmic drugs, such as dronedarone, may well change the approach to rhythm control, for cardioversion of AF and the maintenance of sinus rhythm.18 The BAFTA trial has also shown that elderly AF subjects aged ≥75 years would substantially benefit from anticoagulation therapy rather than aspirin, and even the NICE stroke risk stratification schema may need refinement to reflect this new evidence.15 New oral anticoagulants, such as the oral direct thrombin inhibitors and oral factor Xa inhibitors, are on the horizon, and may also revolutionise the approach to providing thromboprophylaxis in AF, and even remove the confusion for moderate-risk subjects with AF, as a safe anticoagulant without the necessity for monitoring could well be prescribed for all those AF patients at moderate to high risk of stroke, thus avoiding the ambiguity of published stroke risk stratification schema and the perception that aspirin is a true alternative to anticoagulation for stroke prevention in patients with AF.

Clearly, revisions to the NICE guidelines for AF management may soon be needed. For now, at least, the guidelines provide a backbone of evidence-based medicine for clinicians in the UK in the management of AF.

Competing interests

GL has received funding for research, educational symposia, consultancy and lecturing from different manufacturers of drugs used for the treatment of atrial fibrillation and thrombosis. He was clinical adviser to the guideline development group of the atrial fibrillation guidelines,7 and is a coauthor on the 8th American College of Chest Physicians guidelines on antithrombotic therapy for atrial fibrillation (2008).

  • © 2009 Royal College of Physicians

Reference

  1. ↵
    1. Furberg CD
    , Psaty BM, Manolio TA et al. Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study). Am J Cardiol 1994; 74:236–41.doi:10.1016/0002-9149(94)90363-8
    OpenUrlCrossRefPubMed
  2. ↵
    1. Lloyd-Jones DM
    , Wang TJ, Leip EP et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 2004; 110:1042–6.doi:10.1161/01.CIR.0000140263.20897.42
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Heeringa J
    , van der Kuip DA, Hofman A et al. Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study. Eur Heart J 2006; 27:949–53.doi:10.1093/eurheartj/ehi825
    OpenUrlAbstract/FREE Full Text
  4. ↵
    1. Murphy NF
    , Simpson CS, Jhund PS et al. A national survey of the prevalence, incidence, primary care burden and treatment of atrial fibrillation in Scotland. Heart 2007; 93:606–12.doi:10.1136/hrt.2006.107573
    OpenUrlAbstract/FREE Full Text
  5. ↵
    1. Miyasaka Y
    , Barnes ME, Gersh BJ et al. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation 2006; 114:119–25.doi:10.1161/CIRCULATIONAHA.105.595140
    OpenUrlAbstract/FREE Full Text
  6. ↵
    1. Fuster V
    , Ryden LE, Cannom DS et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice guidelines. Europace 2006; 8:651–754.
    OpenUrlFREE Full Text
  7. ↵
    National Collaborating Centre for Chronic Conditions. Atrial fibrillation: national clinical guideline for management in primary and secondary care. London: Royal College of Physicians, 2006.
  8. ↵
    1. Loo B
    , Parnell C, Brook G, Southall E, Mahy I. Atrial fibrillation in a primary care population: how close to NICE guidelines are we? Clin Med 2009; 9: 219–23.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Sudlow CM
    , Rodgers H, Kenny RA, Thomson RG. Service provision and use of anticoagulants in atrial fibrillation. BMJ 1995; 311:588–60.doi:10.1136/bmj.311.7004.558
    OpenUrlFREE Full Text
  10. ↵
    1. Karla L
    , Yu G, Perez I, Lakhani A, Donaldson N. Prospective cohort study to determine if trial efficacy of anticoagulation for stroke prevention in atrial fibrillation translates into clinical effectiveness. BMJ 2000; 320:1236–9.
    OpenUrlAbstract/FREE Full Text
  11. ↵
    Stroke Risk in Atrial Fibrillation Working Group. Comparison of 12 risk stratification schemes to predict stroke in patients with nonvalvular atrial fibrillation. Stroke 2008; 39:1901–10.doi:10.1161/STROKEAHA.107.501825
    OpenUrlAbstract/FREE Full Text
  12. ↵
    1. Lip GYH
    . Risk factors and stroke risk stratification for atrial fibrillation: Limitations and new possibilities. Am Heart J 2008; 156:1–3.doi:10.1016/j.ahj.2008.02.020
    OpenUrlCrossRefPubMed
  13. ↵
    1. Fang MC
    , Go AS, Chang Y et al. ATRIA Study Group. Comparison of risk stratification schemes to predict thromboembolism in people with nonvalvular atrial fibrillation. J Am Coll Cardiol 2008; 51:810–5.
    OpenUrlCrossRefPubMed
  14. ↵
    Stroke Risk in Atrial Fibrillation Working Group. Independent predictors of stroke in patients with atrial fibrillation: a systematic review. Neurology 2007; 69:546–54.doi:10.1212/01.wnl.0000267275.68538.8d
    OpenUrlAbstract/FREE Full Text
  15. ↵
    1. Mant J
    , Hobbs FD, Fletcher K et al. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet 2007; 370: 493–503.doi:10.1016/S0140-6736(07)61233-1
    OpenUrlCrossRefPubMed
  16. ↵
    1. Lip GY
    , Frison L, Grind M. SPORTIF Investigators. Effect of hypertension on anticoagulated patients with atrial fibrillation. Eur Heart J 2007; 28:752–9.
    OpenUrlAbstract/FREE Full Text
  17. ↵
    1. Roy D
    , Talajic M, Nattel S et al. Rhythm control versus rate control for atrial fibrillation and heart failure. N Engl J Med 2008; 358: 2667–77.doi:10.1056/NEJMoa0708789
    OpenUrlCrossRefPubMed
  18. ↵
    1. Stiles S
    . Dronedarone safety, efficacy standings bolstered in huge atrial-fibrillation trial. Accessed at www.theheart.org/article/867591. doi (24 June 2008).
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The management of atrial fibrillation and NICE
Chee W Khoo, Gregory YH Lip
Clinical Medicine Jun 2009, 9 (3) 207-209; DOI: 10.7861/clinmedicine.9-3-207

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The management of atrial fibrillation and NICE
Chee W Khoo, Gregory YH Lip
Clinical Medicine Jun 2009, 9 (3) 207-209; DOI: 10.7861/clinmedicine.9-3-207
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