RT Journal Article SR Electronic T1 What we know so far: COVID-19 current clinical knowledge and research JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 124 OP 127 DO 10.7861/clinmed.2019-coron VO 20 IS 2 A1 Mary A Lake YR 2020 UL http://www.rcpjournals.org/content/20/2/124.abstract AB In December 2019, health authorities in Wuhan, China, identified a cluster of pneumonia cases of unknown aetiology linked to the city's South China Seafood Market. Subsequent investigations revealed a novel coronavirus, SARS-CoV-2, as the causative agent now at the heart of a major outbreak. The rising case numbers have been accompanied by unprecedented public health action, including the wholesale isolation of Wuhan. Alongside this has been a robust scientific response, including early publication of the pathogen genome, and rapid development of highly specific diagnostics. This article will review the new knowledge of SARS-CoV-2 COVID-19 acute respiratory disease, and summarise its clinical features.