RT Journal Article
SR Electronic
T1 SARS-CoV-2 serology: Test, test, test, but interpret with caution!
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP clinmed.2020-0170
DO 10.7861/clinmed.2020-0170
A1 William H Bermingham
A1 Thomas Wilding
A1 Sarah Beck
A1 Aarnoud Huissoon
YR 2020
UL http://www.rcpjournals.org/content/early/2020/06/02/clinmed.2020-0170.abstract
AB SARS-CoV-2 serological tests are a subject of intense interest and have the potential to significantly enhance the diagnostic capability of healthcare services in the current pandemic. However, as with all novel assays, significant validation is required to understand the clinical relevance of results.We present the first study to assess clinician interpretation of SARS-CoV-2 serology scenarios. We identify common key assumptions regarding patient infectivity and protection that are not currently supported by the SARS-CoV-2 evidence base. In this rapidly developing field, we therefore strongly recommend serological assay results are accompanied by clear interpretive support from laboratory and infectious diseases specialists.