RT Journal Article SR Electronic T1 Lessons of the month 1: Polytrauma in a geriatric patient resulting in reactivation of cytomegalovirus infection and secondary cold agglutinin disease-induced haemolytic anaemia JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 433 OP 435 DO 10.7861/clinmed.2020-0176 VO 20 IS 4 A1 Thomas Stockdale A1 Tom Hosack A1 Cameron Griffiths A1 Amit KJ Mandal A1 Constantinos G Missouris YR 2020 UL http://www.rcpjournals.org/content/20/4/433.abstract AB Haemolysis is a rare but serious complication of cytomegalovirus (CMV) infection, described mostly in immunocompromised patients, the pathogenesis of which is yet to be fully elucidated. We describe a case of Coombs-positive haemolytic anaemia in an older Caucasian immunocompetent woman after polytrauma, resulting from suspected reactivation of CMV infection and secondary cold agglutinin disease. Clinicians should consider CMV infection in the differential diagnosis of haemolytic anaemia in immunocompetent older adults who are admitted with significant musculoskeletal trauma. Early treatment with B-cell depletion therapy to halt cold agglutinin production can be life-saving.