TY - JOUR T1 - Images of the month: Crystalglobulin-induced nephropathy JF - Clinical Medicine JO - Clin Med SP - e125 LP - e126 DO - 10.7861/clinmed.2020-0116 VL - 20 IS - 4 AU - Sam LF Lau AU - Fernand M-M Lai AU - Kai-Ming Chow AU - Cheuk-Chun Szeto Y1 - 2020/07/01 UR - http://www.rcpjournals.org/content/20/4/e125.abstract N2 - We report a patient with chronic diabetes and was referred for recent onset proteinuria. Light microscopy of the renal biopsy specimen showed mildly expanded mesangium with mesangial hypercellularity and segmental sclerosis, features compatible with diabetic glomerulosclerosis. However, crystalglobulin-induced nephropathy with crystal deposit was identified on electron microscopy. Renal biopsy is often performed for diabetic patients who present with proteinuria and light microscopy often shows features of diabetic glomerulosclerosis. Additional information may occasionally be revealed on electron microscopy, altering the subsequent plan of management. ER -