RT Journal Article
SR Electronic
T1 Images of the month: Crystalglobulin-induced nephropathy
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP e125
OP e126
DO 10.7861/clinmed.2020-0116
VO 20
IS 4
A1 Sam LF Lau
A1 Fernand M-M Lai
A1 Kai-Ming Chow
A1 Cheuk-Chun Szeto
YR 2020
UL http://www.rcpjournals.org/content/20/4/e125.abstract
AB We report a patient with chronic diabetes and was referred for recent onset proteinuria. Light microscopy of the renal biopsy specimen showed mildly expanded mesangium with mesangial hypercellularity and segmental sclerosis, features compatible with diabetic glomerulosclerosis. However, crystalglobulin-induced nephropathy with crystal deposit was identified on electron microscopy. Renal biopsy is often performed for diabetic patients who present with proteinuria and light microscopy often shows features of diabetic glomerulosclerosis. Additional information may occasionally be revealed on electron microscopy, altering the subsequent plan of management.