TY - JOUR T1 - Lessons of the month 3: ST-elevation myocardial infarction and left ventricular thrombus formation: an arterial thrombotic complication of severe COVID-19 infection JF - Clinical Medicine JO - Clin Med SP - 437 LP - 439 DO - 10.7861/clinmed.2020-0266 VL - 20 IS - 4 AU - Matthew Fenton AU - Seshnag Siddavaram AU - Conn Sugihara AU - Syed Husain Y1 - 2020/07/01 UR - http://www.rcpjournals.org/content/20/4/437.abstract N2 - We describe a case of an 82-year-old man who developed an anterior ST-elevation myocardial infarction (STEMI) and left ventricular thrombus while an inpatient following a diagnosis of severe COVID-19 infection (SARS-CoV-2). His D-dimer was significantly elevated at 12,525 ng/mL (normal range <243). He unfortunately died despite management with thrombolysis, warfarin and non-invasive ventilation. This case provides an example of a likely arterial thrombotic complication of severe COVID-19 infection. Clinicians should be aware of this possibility in such patients, with a severely prothrombotic state as a possible underlying aetiology. Further research is required to establish any causative link, pathophysiological mechanisms and whether modification to existing venous thromboembolism prophylaxis strategies may also reduce arterial thrombotic complications of severe COVID-19 infection. ER -