PT  - JOURNAL ARTICLE
AU  - William H Bermingham
AU  - Thomas Wilding
AU  - Sarah Beck
AU  - Aarnoud Huissoon
TI  - SARS-CoV-2 serology: Test, test, test, but interpret with caution!
AID  - 10.7861/clinmed.2020-0170
DP  - 2020 Jul 01
TA  - Clinical Medicine
PG  - 365--368
VI  - 20
IP  - 4
4099  - http://www.rcpjournals.org/content/20/4/365.short
4100  - http://www.rcpjournals.org/content/20/4/365.full
SO  - Clin Med2020 Jul 01; 20
AB  - SARS-CoV-2 serological tests are a subject of intense interest and have the potential to significantly enhance the diagnostic capability of healthcare services in the current pandemic. However, as with all novel assays, significant validation is required to understand the clinical relevance of results. We present the first study to assess clinician interpretation of SARS-CoV-2 serology scenarios. We identify common key assumptions regarding patient infectivity and protection that are not currently supported by the SARS-CoV-2 evidence base. In this rapidly developing field, we therefore strongly recommend serological assay results are accompanied by clear interpretive support from laboratory and infectious diseases specialists.