PT  - JOURNAL ARTICLE
AU  - Wan Zhu
AU  - Wenxia Cao
AU  - Xuting Zheng
AU  - Xuena Li
AU  - Yaming Li
AU  - Baiyi Chen
AU  - Jingping Zhang
TI  - The diagnostic value of <sup>18</sup>F-FDG PET/CT in identifying the causes of fever of unknown origin
AID  - 10.7861/clinmed.2020-0268
DP  - 2020 Sep 01
TA  - Clinical Medicine
PG  - 449--453
VI  - 20
IP  - 5
4099  - http://www.rcpjournals.org/content/20/5/449.short
4100  - http://www.rcpjournals.org/content/20/5/449.full
SO  - Clin Med2020 Sep 01; 20
AB  - Background This study investigated the clinical significance of 18F-fluorodeoxyglucose positron emission tomography / computed tomography (18F-FDG PET/CT) in identifying the causes of fever of unknown origin (FUO).Methods Patients with a fever who received an 18F-FDG PET/CT examination were retrospectively selected. The means of the two groups were compared using an independent-samples t-test.Results Among the 89 included patients, 66 were diagnosed using 18F-FDG PET/CT. The sensitivity, specificity and diagnostic accuracy of 18F-FDG PET/CT for the diagnosis of patients with FUO were 84.5%, 25.8%, and 64.0%, respectively. The detection rates of 18F-FDG PET/CT for neoplastic diseases, infectious diseases and non-infectious inflammatory diseases were 100%, 61.3%, and 75%, respectively. The difference in C-reactive protein (CRP) levels between the two groups was statistically significant.Conclusions 18F-FDG PET/CT has great clinical importance in diagnosing and identifying causes of FUO and improves the accuracy of FUO diagnosis when combined with serum CRP levels.