RT Journal Article SR Electronic T1 The diagnostic value of 18F-FDG PET/CT in identifying the causes of fever of unknown origin JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 449 OP 453 DO 10.7861/clinmed.2020-0268 VO 20 IS 5 A1 Wan Zhu A1 Wenxia Cao A1 Xuting Zheng A1 Xuena Li A1 Yaming Li A1 Baiyi Chen A1 Jingping Zhang YR 2020 UL http://www.rcpjournals.org/content/20/5/449.abstract AB Background This study investigated the clinical significance of 18F-fluorodeoxyglucose positron emission tomography / computed tomography (18F-FDG PET/CT) in identifying the causes of fever of unknown origin (FUO).Methods Patients with a fever who received an 18F-FDG PET/CT examination were retrospectively selected. The means of the two groups were compared using an independent-samples t-test.Results Among the 89 included patients, 66 were diagnosed using 18F-FDG PET/CT. The sensitivity, specificity and diagnostic accuracy of 18F-FDG PET/CT for the diagnosis of patients with FUO were 84.5%, 25.8%, and 64.0%, respectively. The detection rates of 18F-FDG PET/CT for neoplastic diseases, infectious diseases and non-infectious inflammatory diseases were 100%, 61.3%, and 75%, respectively. The difference in C-reactive protein (CRP) levels between the two groups was statistically significant.Conclusions 18F-FDG PET/CT has great clinical importance in diagnosing and identifying causes of FUO and improves the accuracy of FUO diagnosis when combined with serum CRP levels.