PT  - JOURNAL ARTICLE
AU  - Ayman S Bannaga
AU  - Maria Tabuso
AU  - Alexia Farrugia
AU  - Subashini Chandrapalan
AU  - Karenjit Somal
AU  - Voon Kune Lim
AU  - Shahd Mohamed
AU  - Gohar J Nia
AU  - Jayan Mannath
AU  - John LH Wong
AU  - Angela Noufaily
AU  - Benjamin R Disney
AU  - Ramesh P Arasaradnam
TI  - C-reactive protein and albumin association with mortality of hospitalised SARS-CoV-2 patients: A tertiary hospital experience
AID  - 10.7861/clinmed.2020-0424
DP  - 2020 Sep 01
TA  - Clinical Medicine
PG  - 463--467
VI  - 20
IP  - 5
4099  - http://www.rcpjournals.org/content/20/5/463.short
4100  - http://www.rcpjournals.org/content/20/5/463.full
SO  - Clin Med2020 Sep 01; 20
AB  - Objective The objective was to study hospitalised COVID-19 patients’ mortality and intensive care unit (ICU) admission with covariates of interest (age, gender, ethnicity, clinical presentation, comorbidities and admission laboratory findings).Methods Logistic regression analyses were performed for patients admitted to University Hospital, University Hospitals Coventry and Warwickshire NHS Trust, between 24 January 2020 – 13 April 2020.Results There were 321 patients hospitalised. Median age was 73 years and 189 (59%) were male. Ethnicity was divided between Caucasian (77%), and black, Asian, and minority ethnic (BAME) groups (23%). Commonest symptoms were dyspnoea (62.9%), fever (59.1%) and cough (56%). Gastrointestinal symptoms amounted to 11.8%.Forty-four patients (13.7%) received ICU care. ICU male to female ratio was 3:1 (p=0.027; odds ratio (OR) 2.3; 95% confidence interval (CI) 1.1–4.9), BAME (p=0.008; OR 2.5; 95% CI 1.3–4.9), age >65 years (p=0.026; OR 0.28; 95% CI 0.09–0.93), heart disease (p=0.009; OR 0.2; 95% CI 0.1–0.6) and elevated C-reactive protein (CRP; p<0.001; OR 1.004; 95% CI 1.002–1.008) were associated with ICU admission.One-hundred and four patients (32.4%) died. Age >65 years (p=0.011; OR 5; 95% CI 1.6–21.9), neutrophils (p=0.047), neutrophil:lymphocyte ratio (NLR; p=0.028), CRP (p<0.001) and albumin (p=0.002) were associated with mortality. When analysis adjusted for age, CRP (p<0.001; OR 1.006; 95% CI 1.004–1.008) and albumin (p=0.005; OR 0.94; 95% CI 0.90–0.98) remained associated with mortality.Conclusions COVID-19 has high mortality. BAME and male patients were associated with ICU admission. High CRP and low albumin (after correcting for age) were associated with mortality.