RT Journal Article
SR Electronic
T1 C-reactive protein and albumin association with mortality of hospitalised SARS-CoV-2 patients: A tertiary hospital experience
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 463
OP 467
DO 10.7861/clinmed.2020-0424
VO 20
IS 5
A1 Ayman S Bannaga
A1 Maria Tabuso
A1 Alexia Farrugia
A1 Subashini Chandrapalan
A1 Karenjit Somal
A1 Voon Kune Lim
A1 Shahd Mohamed
A1 Gohar J Nia
A1 Jayan Mannath
A1 John LH Wong
A1 Angela Noufaily
A1 Benjamin R Disney
A1 Ramesh P Arasaradnam
YR 2020
UL http://www.rcpjournals.org/content/20/5/463.abstract
AB Objective The objective was to study hospitalised COVID-19 patients’ mortality and intensive care unit (ICU) admission with covariates of interest (age, gender, ethnicity, clinical presentation, comorbidities and admission laboratory findings).Methods Logistic regression analyses were performed for patients admitted to University Hospital, University Hospitals Coventry and Warwickshire NHS Trust, between 24 January 2020 – 13 April 2020.Results There were 321 patients hospitalised. Median age was 73 years and 189 (59%) were male. Ethnicity was divided between Caucasian (77%), and black, Asian, and minority ethnic (BAME) groups (23%). Commonest symptoms were dyspnoea (62.9%), fever (59.1%) and cough (56%). Gastrointestinal symptoms amounted to 11.8%.Forty-four patients (13.7%) received ICU care. ICU male to female ratio was 3:1 (p=0.027; odds ratio (OR) 2.3; 95% confidence interval (CI) 1.1–4.9), BAME (p=0.008; OR 2.5; 95% CI 1.3–4.9), age >65 years (p=0.026; OR 0.28; 95% CI 0.09–0.93), heart disease (p=0.009; OR 0.2; 95% CI 0.1–0.6) and elevated C-reactive protein (CRP; p<0.001; OR 1.004; 95% CI 1.002–1.008) were associated with ICU admission.One-hundred and four patients (32.4%) died. Age >65 years (p=0.011; OR 5; 95% CI 1.6–21.9), neutrophils (p=0.047), neutrophil:lymphocyte ratio (NLR; p=0.028), CRP (p<0.001) and albumin (p=0.002) were associated with mortality. When analysis adjusted for age, CRP (p<0.001; OR 1.006; 95% CI 1.004–1.008) and albumin (p=0.005; OR 0.94; 95% CI 0.90–0.98) remained associated with mortality.Conclusions COVID-19 has high mortality. BAME and male patients were associated with ICU admission. High CRP and low albumin (after correcting for age) were associated with mortality.