%0 Journal Article %A Abigail Holborow %A Hibo Asad %A Lavinia Porter %A Poppy Tidswell %A Claire Johnston %A Ian Blyth %A Alice Bone %A Brendan Healy %T The clinical sensitivity of a single SARS-CoV-2 upper respiratory tract RT-PCR test for diagnosing COVID-19 using convalescent antibody as a comparator %D 2020 %R 10.7861/clinmed.2020-0555 %J Clinical Medicine %P clinmed.2020-0555 %X The clinical false negative rate of reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 on a single upper respiratory tract sample was calculated using convalescent antibody testing as a comparator. The sensitivity in symptomatic individuals was 86.2% (25/29). Of the missed cases, one (3.5%) was detected by repeat RT-PCR, one by CT thorax and two (7.1%) by convalescent antibody. The clinical false negative rate of a single RT-PCR on an upper respiratory tract sample of 14% in symptomatic patients is reassuring when compared to early reports. This report supports a strategy of combining repeat swabbing, use of acute and convalescent antibody testing and CT thorax for COVID-19 diagnosis. %U https://www.rcpjournals.org/content/clinmedicine/early/2020/09/10/clinmed.2020-0555.full.pdf