@article {Jones600, author = {Eleanor Jones and Udayaraj Umasankar and Habeeba Mallu and Timothy Hampton and Angela Kulendran and Mehool Patel}, title = {Lesson of the month: Oxycodone-induced leukoencephalopathy: a rare diagnosis}, volume = {20}, number = {6}, pages = {600--602}, year = {2020}, doi = {10.7861/clinmed.2020-06500-0-0}, publisher = {Royal College of Physicians}, abstract = {Oxycodone-induced leukoencephalopathy is a rare diagnosis that should be considered in unconscious patients with appropriate history. We describe a case of a 57-year-old unconscious woman who required intubation and did not respond to naloxone infusion. The unconsciousness was initially thought to be due to hypoxic brain injury. However, a further review of brain imaging showed characteristic features of oxycodone-induced leukoencephalopathy. We describe the pathological and radiological features of this condition, and provide a concise review of the limited literature on this condition. Accurate diagnosis of this condition will be valuable to clinicians and patients in terms of their medium-term and long-term prognosis, and potential for rehabilitation.}, issn = {1470-2118}, URL = {https://www.rcpjournals.org/content/20/6/600}, eprint = {https://www.rcpjournals.org/content/20/6/600.full.pdf}, journal = {Clinical Medicine} }