TY - JOUR T1 - Lesson of the month: Oxycodone-induced leukoencephalopathy: a rare diagnosis JF - Clinical Medicine JO - Clin Med SP - 600 LP - 602 DO - 10.7861/clinmed.2020-06500-0-0 VL - 20 IS - 6 AU - Eleanor Jones AU - Udayaraj Umasankar AU - Habeeba Mallu AU - Timothy Hampton AU - Angela Kulendran AU - Mehool Patel Y1 - 2020/11/01 UR - http://www.rcpjournals.org/content/20/6/600.abstract N2 - Oxycodone-induced leukoencephalopathy is a rare diagnosis that should be considered in unconscious patients with appropriate history. We describe a case of a 57-year-old unconscious woman who required intubation and did not respond to naloxone infusion. The unconsciousness was initially thought to be due to hypoxic brain injury. However, a further review of brain imaging showed characteristic features of oxycodone-induced leukoencephalopathy. We describe the pathological and radiological features of this condition, and provide a concise review of the limited literature on this condition. Accurate diagnosis of this condition will be valuable to clinicians and patients in terms of their medium-term and long-term prognosis, and potential for rehabilitation. ER -