RT Journal Article
SR Electronic
T1 Lesson of the month: Severe granulomatosis with polyangiitis (GPA): a diagnostic challenge during the COVID-19 pandemic
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 79
OP 80
DO 10.7861/clinmed.2020-0793
VO 21
IS 1
A1 Qurratulain Qurratulain
A1 Azeem Ahmed
A1 Quentin Jones
YR 2021
UL http://www.rcpjournals.org/content/21/1/79.abstract
AB We present the case of a 71-year-old woman with bilateral pneumonia who continued to deteriorate despite multiple courses of antibiotics. When dexamethasone was added to cover the possibility of COVID-19 pneumonia, she rapidly improved. Subsequently, she was found to have a strongly positive PR3 anti-nuclear cytoplasmic antibody (ANCA) and clinical features consistent with granulomatosis with polyangiitis (GPA) with upper respiratory tract and renal involvement. The case highlights how the COVID-19 pandemic can create new challenges in the diagnosis of GPA.