PT  - JOURNAL ARTICLE
AU  - Jack West
AU  - Serenydd Everden
AU  - Nikitas Nikitas
TI  - A case of COVID-19 reinfection in the UK
AID  - 10.7861/clinmed.2020-0912
DP  - 2021 Jan 01
TA  - Clinical Medicine
PG  - e52--e53
VI  - 21
IP  - 1
4099  - http://www.rcpjournals.org/content/21/1/e52.short
4100  - http://www.rcpjournals.org/content/21/1/e52.full
SO  - Clin Med2021 Jan 01; 21
AB  - Protective immunity following COVID-19 infection is not yet fully understood. An understanding of COVID-19 reinfection will be key in guiding government and public health policy decisions in the coming months. This report describes two distinct infective episodes of COVID-19 occurring in the same individual, at the time of writing the first published case in the UK. In April 2020 a 25-year-old UK doctor exhibited classical COVID-19 symptoms, including fevers, headaches, and fatigue. A COVID-19 nucleic acid amplification test (NAAT) at the time returned negative. However, a follow-up antibody test in May 2020 returned positive. In October 2020 the same individual exhibited coryzal symptoms and headaches. He was COVID-19 NAAT tested and found to be positive. There was exposure to high viral load prior to reinfection. Overall the second infection was symptomatically milder, with a faster recovery. This evidence for reinfection poses challenges for public health and vaccination efforts to protect against the COVID-19 pandemic.