RT Journal Article
SR Electronic
T1 The challenges of chronic pain and fatigue
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 19
OP 27
DO 10.7861/clinmed.2020-1009
VO 21
IS 1
A1 Jessica A Eccles
A1 Kevin A Davies
YR 2021
UL http://www.rcpjournals.org/content/21/1/19.abstract
AB In this review, we explore the challenges of chronic pain and fatigue in clinical practice. Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the ‘clinical problem’. We explore commonly associated symptoms and possible pathological associations, including variant connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation, dysregulated inflammatory and interoceptive processes, which may inform treatment targets. We suggest a multidisciplinary management approach.