%0 Journal Article %A Leticia Sanz-Canalejas %A María del Carmen Polidura-Arruga %A Miguel Yus-Fuertes %A Manuela Jorquera-Moya %A Nieves Vidart-Simón %A Juan Arrazola-García %A Natividad Gómez-Ruiz %T Lesson of the month: Severe leukoencephalopathy by SARS-CoV-2 %D 2021 %R 10.7861/clinmed.2020-0940 %J Clinical Medicine %P 155-157 %V 21 %N 2 %X Neurological manifestations associated with SARS-CoV-2 infection as well as its pathogenesis are insufficiently explained. We present two cases of severe COVID-19 who required hospitalisation in the intensive care unit with persistently depressed mental status and severe leukoencephalopathy. We discuss the clinical and radiological findings and also propose the possible pathogenesis involved. %U https://www.rcpjournals.org/content/clinmedicine/21/2/155.full.pdf