RT Journal Article SR Electronic T1 Lesson of the month: Severe leukoencephalopathy by SARS-CoV-2 JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 155 OP 157 DO 10.7861/clinmed.2020-0940 VO 21 IS 2 A1 Leticia Sanz-Canalejas A1 María del Carmen Polidura-Arruga A1 Miguel Yus-Fuertes A1 Manuela Jorquera-Moya A1 Nieves Vidart-Simón A1 Juan Arrazola-García A1 Natividad Gómez-Ruiz YR 2021 UL http://www.rcpjournals.org/content/21/2/155.abstract AB Neurological manifestations associated with SARS-CoV-2 infection as well as its pathogenesis are insufficiently explained. We present two cases of severe COVID-19 who required hospitalisation in the intensive care unit with persistently depressed mental status and severe leukoencephalopathy. We discuss the clinical and radiological findings and also propose the possible pathogenesis involved.