PT - JOURNAL ARTICLE AU - Charlotte E Gollins AU - David de Berker TI - Nails in systemic disease AID - 10.7861/clinmed.2021-0243 DP - 2021 May 01 TA - Clinical Medicine PG - 166--169 VI - 21 IP - 3 4099 - http://www.rcpjournals.org/content/21/3/166.short 4100 - http://www.rcpjournals.org/content/21/3/166.full SO - Clin Med2021 May 01; 21 AB - A change in colour, size, shape or texture of finger- and toenails can be an indicator of underlying systemic disease. An appreciation of these nail signs, and an ability to interpret them when found, can help guide diagnosis and management of a general medical patient. This article discusses some common, and some more rare, nail changes associated with systemic disease.