RT Journal Article SR Electronic T1 Nails in systemic disease JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 166 OP 169 DO 10.7861/clinmed.2021-0243 VO 21 IS 3 A1 Charlotte E Gollins A1 David de Berker YR 2021 UL http://www.rcpjournals.org/content/21/3/166.abstract AB A change in colour, size, shape or texture of finger- and toenails can be an indicator of underlying systemic disease. An appreciation of these nail signs, and an ability to interpret them when found, can help guide diagnosis and management of a general medical patient. This article discusses some common, and some more rare, nail changes associated with systemic disease.