@article {Ken-Drore290, author = {Gie Ken-Dror and Charles Wade and Shyam S Sharma and Melanie Irvin-Sellers and Jonathan Robin and David Fluck and Paul Bentley and Pankaj Sharma}, title = {SARS-CoV-2 antibody seroprevalence in NHS healthcare workers in a large double-sited UK hospital}, volume = {21}, number = {3}, pages = {e290--e294}, year = {2021}, doi = {10.7861/clinmed.2020-1096}, publisher = {Royal College of Physicians}, abstract = {We determined the seroprevalence of SARS-CoV-2 antibodies in NHS healthcare workers (HCWs) in a cross-sectional study from a large general hospital located in a double-sited rural and semi-rural area. The sample size of 3,119 HCWs (mean age 43{\textpm}13) consisted of 75.2\% women, 61.1\% White individuals and predominantly (62.4\%) asymptomatic individuals. Seroprevalence of SARS-CoV-2 antibodies was 19.7\%. Determinants of seropositivity were preceding symptomatic infection and non-White ethnicity. Regardless of staff role or sex, multivariate regression analysis revealed that non-White HCWs were three times (odds ratio [OR] 3.12, 95\% confidence interval [CI] 2.53{\textendash}3.86, P\<0.001) more likely to have antibodies than White staff, and seven times (OR 7.10, 95\% CI 5.72{\textendash}8.87, P\<0.001) more likely if there was a history of preceding symptoms. We report relatively high rates of seropositivity in all NHS healthcare workers. Non-White symptomatic HCWs were significantly more likely to be seropositive than their colleagues, independent of age, sex or staff role.}, issn = {1470-2118}, URL = {https://www.rcpjournals.org/content/21/3/e290}, eprint = {https://www.rcpjournals.org/content/21/3/e290.full.pdf}, journal = {Clinical Medicine} }