TY - JOUR T1 - Lesson of the month: Acute pancreatitis due to hypertriglyceridaemia in a transgender woman: a complication of high-dose oral oestrogen therapy? JF - Clinical Medicine JO - Clin Med SP - 228 LP - 230 DO - 10.7861/clinmed.2021-0075 VL - 21 IS - 3 AU - Aisha Hashmi AU - Emilia I Smith AU - Andra Ciutac AU - Jamie C Smith Y1 - 2021/05/01 UR - http://www.rcpjournals.org/content/21/3/228.abstract N2 - Acute pancreatitis (AP) is a medical emergency associated with significant morbidity and mortality. Hypertriglyceridaemia is a well-established but often neglected cause of AP, associated with delayed diagnosis and worse outcome than other more common causes of AP. Although oestrogen-induced hypertriglyceridaemia is known to be a rare cause of AP in females, it is much less well-recognised in biological males. We report the case of a 52-year-old transgender woman receiving high-dose oral oestrogen therapy who was admitted with abdominal pain and found to have AP caused by severe hypertriglyceridaemia. We describe the features underlying the management of AP caused by hypertriglyceridaemia and review the link between oral oestrogen, hypertriglyceridaemia and AP.Given the growth in transgender medicine leading to increasing use of therapeutic high-dose oestrogens in biological males for gender reassignment, it is important that clinicians are alert to the phenomenon of oestrogen-induced-hypertriglyceridaemia and its associated risk of AP. ER -