RT Journal Article SR Electronic T1 De Testimonio: on the evidence for decisions about the use of therapeutic interventions JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 579 OP 588 DO 10.7861/clinmedicine.8-6-579 VO 8 IS 6 A1 Michael Rawlins YR 2008 UL http://www.rcpjournals.org/content/8/6/579.abstract AB Decisions about the use of therapeutic interventions, whether for individuals or entire healthcare systems, should be based on the totality of the available evidence. The notion that evidence can be reliably or usefully placed in ‘hierarchies’ is illusory. Rather, decision makers need to exercise judgement about whether (and when) evidence gathered from experimental or observational sources is fit for purpose.