RT Journal Article SR Electronic T1 Pain symptoms in depression: definition and clinical significance JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 390 OP 395 DO 10.7861/clinmedicine.5-4-390 VO 5 IS 4 A1 Cornelius Katona A1 Robert Peveler A1 Christopher Dowrick A1 Simon Wessely A1 Charlotte Feinmann A1 Linda Gask A1 Huw Lloyd A1 Amanda C de C Williams A1 Elizabeth Wager YR 2005 UL http://www.rcpjournals.org/content/5/4/390.abstract AB This article presents the findings of a focused literature review and consensus meetings on the definition and clinical significance of painful symptoms in patients with depression. About 50% of depressed patients report pain, and many types of pain occur more frequently in people with depression than in those without. There is some evidence that pain in depressed patients is associated with a poor response to treatment. Pain and depression may share common pathways and may both respond to treatment with certain antidepressants. Doctors need to be alert to pain in depressed patients and be prepared to treat it.