RT Journal Article SR Electronic T1 Research into ageing and frailty JF Future Healthcare Journal JO Future Healthc J FD Royal College of Physicians SP e237 OP e242 DO 10.7861/fhj.2021-0088 VO 8 IS 2 A1 Adam L Gordon A1 Miles D Witham A1 Emily J Henderson A1 Rowan H Harwood A1 Tahir Masud YR 2021 UL http://www.rcpjournals.org/content/8/2/e237.abstract AB Research into ageing covers opportunities and challenges posed by an older population, and research to understand the ageing processes across the lifespan. The evidence base for Comprehensive Geriatric Assessment (CGA) is well established and efforts should now shift to understanding how to implement its principles across different healthcare contexts. Research around syndromes common in older people has progressed with variable success; while effective therapies for falls and cognitive impairment have been identified, older people with advanced frailty have commonly been excluded from Parkinson's disease and continence research. Research to understand the mechanisms of ageing has potential to mitigate against or treat emerging sarcopenia and cognitive impairment, and thus modify frailty trajectories. Pharmacogenetics could individualise therapeutics to reduce polypharmacy. These issues can only be addressed with development of infrastructure, capacity and expertise in ageing research. Commonly used research methodologies must be adapted to take account of frailty, cognitive impairment and functional dependency.