PT - JOURNAL ARTICLE AU - Sarah LW Fang AU - Livia Teo AU - Cheng Yi Loo AU - James W Li AU - Anindita Santosa TI - Lessons of the month 2: Ocular manifestations and complications of hepatitis C infection AID - 10.7861/clinmed.2021-0320 DP - 2021 Jul 01 TA - Clinical Medicine PG - e417--e419 VI - 21 IP - 4 4099 - http://www.rcpjournals.org/content/21/4/e417.short 4100 - http://www.rcpjournals.org/content/21/4/e417.full SO - Clin Med2021 Jul 01; 21 AB - We present a case of a man with hepatitis C with acute visual loss in his left eye over a 3-day period. Initial evaluation suggested a possible idiopathic orbital inflammatory syndrome as underlying cause for his symptoms. Initial response to systemic glucocorticoids and antiviral treatment were encouraging with improvement in the patient's visual acuity. After a period of loss to follow up and discontinuation of treatment, the patient re-presented with visual loss in his left eye. Re-evaluation confirmed a diagnosis of marginal zone B-cell lymphoma. This case illustrates the importance of considering the various ocular manifestations of hepatitis C.